Video

Dr Katie Lunnon talks about her research, which explores the genomic factors in dementia.

Genomics of dementia

Our Complex Disease (Epi)genomics Group uses cutting-edge methods to explore the causes and consequences of molecular variation in the brain, and the role this may play in aging and the onset of diseases including dementia.

We study the epigenetic processes that regulate gene expression, and explore how changes in gene function impact human health. There is growing interest in the role of epigenetic variation in mediating the interplay between genes and the environment. Disease-associated epigenetic marks are potentially reversible, therefore representing possible targets for the development of new drugs.

We use novel genomic profiling methods and sophisticated bioinformatics analyses to explore regulatory genomic variation in post-mortem brain samples, population-based cohorts and established models (animal and cellular) of dementia.

Genomics of dementia - primary investigators

NameRoleKeywords
Professor Jonathan Mill  Professor of Epigenetics Genomics, epigenetics, gene function, animal models, brain, transcription, bioinformatics
Dr Katie Lunnon Associate Professor in Epigenetics Genomics, epigenetics, gene function, animal models, brain, transcription, bioinformatics
Dr Byron Creese Senior Research Fellow Genomics, genome-wide data analysis, neuropsychiatric symptoms in dementia
Dr Eilis Hannon Research Fellow Genomics, psychiatric disorders, bioinformatics
Dr Rebecca Smith Research Fellow Epigenetics, Alzheimer’s Disease
Dr Ehsan Pishva Research Fellow Epigenetics, stress, depression, Alzheimer’s Disease