Inflammation in an islet from an individual with Type 1 diabetes

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Professor Noel Morgan describes his research into the future prevention of type 1 diabetes

Cell biology of diabetes

Our world-leading research looks at cell function and behaviour to learn more about diabetes mechanisms and progression, with a view to finding new treatments.

Our Islet Biology researchers examine the mechanisms that lead to beta-cell dysfunction and death in both type 1 and type 2 diabetes. Our work in type 1 diabetes makes use of a unique cohort of pancreas samples recovered from patients who died soon after diagnosis, to study the natural history of the disease. In addition, we employ cell culture models to study the role of fatty acids as regulators of beta-cell viability.

We are also investigating how the brain controls food intake and body weight, and fat (adipose) tissue, which is an important metabolic organ with a key role in the storage of surplus energy derived from macronutrients (sugar and other carbohydrates, proteins and fats) from the diet.

Cell biology of Diabetes - primary investigators

Name RoleKeywords
Dr Kate Ellacott  Senior Lecturer Animal models, hyperglycaemia, hypoglycaemia, impaired glucose tolerance, insulin resistance, obesity, type 2 diabetes, neuroendocrinology, brain
Professor Noel Morgan Professor of Endocrine Pharmacology Diabetes mellitus, autoimmune disease, pancreas, type 1, type 2, beta-cells, islets of Langerhans, enterovirus, insulitis, insulin secretion, proinsulin
Dr Craig Beall Research Fellow AMP-activated protein kinase, Brain, neurons, Astrocytes, Diabetes complications, Glucose sensing hyperglycaemia, hypoglycaemia, Inflammation, Obesity, Pancreas, Physiology, Liver, Muscle
Dr Katarina Kos  Senior Lecturer (E&R) (Clinical) Adipose tissue function, gene and protein expression and function, human physiology, weight loss, obesity related complications, fatty liver disease, tissue oxygenation, vascular disease
Associate Professor Lorna Harries Associate Professor Molecular Genetics Ageing, Molecular Genetics, Type 2 Diabetes, gene expression, gene regulation
Dr Sarah Richardson

Senior Lecturer

Autoantibodies, autoimmune disease, diabetes mellitus, diabetes risk factors, diagnosis, insulin, islet antibodies, pancreas, prediabetes, public and patient involvement, risk factors of diabetes, translational research, type 1 diabetes, type 2 diabetes, β cells, enterovirus, pancreas pathology, B cells
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Dr Kate Ellacott - molecular mechanisms which control food intake and body weight by the brain