Inflammation in an islet from an individual with Type 1 diabetes
Professor Noel Morgan describes his research into the future prevention of type 1 diabetes
Cell biology of diabetes
Our world-leading research looks at cell function and behaviour to learn more about diabetes mechanisms and progression, with a view to finding new treatments.
Our Islet Biology researchers examine the mechanisms that lead to beta-cell dysfunction and death in both type 1 and type 2 diabetes. Our work in type 1 diabetes makes use of a unique cohort of pancreas samples recovered from patients who died soon after diagnosis, to study the natural history of the disease. In addition, we employ cell culture models to study the role of fatty acids as regulators of beta-cell viability.
We are also investigating how the brain controls food intake and body weight, and fat (adipose) tissue, which is an important metabolic organ with a key role in the storage of surplus energy derived from macronutrients (sugar and other carbohydrates, proteins and fats) from the diet.
Cell biology of Diabetes - primary investigators
|Dr Kate Ellacott||Senior Lecturer||Animal models, hyperglycaemia, hypoglycaemia, impaired glucose tolerance, insulin resistance, obesity, type 2 diabetes, neuroendocrinology, brain|
|Professor Noel Morgan||Professor of Endocrine Pharmacology||Diabetes mellitus, autoimmune disease, pancreas, type 1, type 2, beta-cells, islets of Langerhans, enterovirus, insulitis, insulin secretion, proinsulin|
|Dr Craig Beall||Research Fellow||AMP-activated protein kinase, Brain, neurons, Astrocytes, Diabetes complications, Glucose sensing hyperglycaemia, hypoglycaemia, Inflammation, Obesity, Pancreas, Physiology, Liver, Muscle|
|Dr Katarina Kos||Senior Lecturer (E&R) (Clinical)||Adipose tissue function, gene and protein expression and function, human physiology, weight loss, obesity related complications, fatty liver disease, tissue oxygenation, vascular disease|
|Associate Professor Lorna Harries||Associate Professor Molecular Genetics||Ageing, Molecular Genetics, Type 2 Diabetes, gene expression, gene regulation|
|Dr Sarah Richardson||
|Autoantibodies, autoimmune disease, diabetes mellitus, diabetes risk factors, diagnosis, insulin, islet antibodies, pancreas, prediabetes, public and patient involvement, risk factors of diabetes, translational research, type 1 diabetes, type 2 diabetes, β cells, enterovirus, pancreas pathology, B cells|
Dr Kate Ellacott - molecular mechanisms which control food intake and body weight by the brain