Treatment response

Professor Andrew Hattersley’s team first discovered that neonatal diabetes was caused by a single gene mutation that rendered the pancreas’ potassium channels unresponsive. They developed a life-changing treatment that allowed these patients to take daily tablets rather than insulin injections. The Exeter diabetes team have found the single genetic mutation that cause 15 different sub-types of diabetes. Identifying the cause means getting the right treatment and support for people with diabetes.

Treatment Response - primary investigators

Name	Role	Keywords
Dr Angus Jones	NIHR Clinician Scientist	Type1, Type 2, insulin, c-peptide, classification, biomarkers, diagnosis, hypoglycaemia
Dr Timothy McDonald	NIHR Clinical Scientist	Monogenic diabetes, insulin production, c-peptide, creatinine, type 2, glycaemic deterioration, biomarkers, genetics
Professor Maggie Shepherd	Honorary Clinical Professor	Monogenetic diabetes, genetics, misdiagnosis, patient experience, type 1, type 2, c-peptide, clinical care
Professor Andrew Hattersley	Gillings Chair of Precision Medicine, Professor of Molecular Medicine & Consultant Physician	MODY, Neonatal diabetes, islet antibodies, gestational diabetes, genetic risk score, Bioinformatics, BMI Diagnosis
Dr Katarina Kos	Senior Lecturer (E&R) (Clinical)	adipose tissue function, gene and protein expression and function, human physiology, weight loss, obesity related complications, fatty liver disease, tissue oxygenation, vascular disease
Dr Richard Oram	Harry Keen Research fellow	β cells, Type 1 diabetes, C-peptide, translational research, autoantibodies, autoimmune disease, Type 1 diabetes, Genetic risk score, T1D GRS, Extremely early onset type 1 diabetes
Dr Mitra Tavakoli	Senior Lecturer (E&R)	Microvascular Complications, Ophthalmic markers, Early Diagnosis, Screening , Implementation, Neurodegenerative biomarkers