Professor Sian Ellard - research into neonatal diabetes and hyperinsulinism
Professor Andrew Hattersley - From base change to better care in diabetes
Professor Lorna Harries - regulation and expression of genes in ageing and diabetes
Dr Rachel Freathy - how a baby’s genes influence birth weight and later life
Diabetes is caused by a combination of genetic and environmental risk factors, or in rarer cases, can be directly inherited due to single gene mutations in the DNA. Researchers at the University of Exeter Medical School studying the polygenic, monogenic, mitochondrial and epigenetic causes of diabetes inheritance have made ground-breaking discoveries that have transformed scientific understanding and clinical care for over 20 years.
Through genomics research, the Exeter diabetes teams seek to understand the causes and consequences of diabetes, identify those most at risk and create interventions designed to mitigate those risks, predict, detect and prevent.
The Medical School is a partner in the South West NHS Genomic Medicine Centre and is contributing to the 100,000 Genomes Project. Our MSc in Genomic Medicine is upskilling a new generation of health professionals to be at the forefront of knowledge and technology.
Genomic Medicine - primary investigators
|Professor Andrew Hattersley||Gillings Chair of Precision Medicine, Professor of Molecular Medicine & Consultant Physician||MODY, Neonatal diabetes, islet antibodies, gestational diabetes, genetic risk score, Bioinformatics, BMI Diagnosis|
|Professor Andrew Crosby||Professor of Human Genetics||Genetics, Neurological diseases, Pathogenic mechanisms, Cardiovascular disease, Mutations, therapeutic approaches, inherited diseases, communities|
|Professor Sian Ellard||Professor of Genomic Medicine||Monogenic diabetes, neonatal diabetes, hyperinsulinism, next generation sequencing technology|
|Dr Sarah Flanagan||Sir Henry Dale Fellow||Diabetes Mellitus Genetic Screening Hyperglycaemia Hyperinsulinism Hypoglycaemia Insulin Molecular Genetics Monogenic autoimmune disease Monogenic Diabetes Neonatal Diabetes|
|Professor of Human Genetics||Bioinformatics, BMI, diabetes mellitus, diabetes risk factors, genetic risk score, genetic screening, genomic-wide association studies, hyperglycaemia, hyperinsulinism, impaired glucose tolerance, insulin, insulin resistance, microalbuminuria, molecular genetics, obesity, pancreas, polygenic diabetes, prediabetes, public and patient involvement, risk factors of diabetes, type 2, β cells|
|Sir Henry Dale Fellow||Birth weight, pregnancy, genome-wide association studies, polygenic diabetes, type 2 diabetes, gestational diabetes, bioinformatics, genetic risk score, hyperglycaemia|
|Associate Professor Molecular Genetics||Ageing, Molecular Genetics, Type 2 Diabetes, gene expression, gene regulation|
|Associate Professor||Bioinformatics, diabetes mellitus, genetic risk score, genomic-wide association studies, MODY, molecular genetics, monogenic diabetes, obesity, polygenic diabetes, risk factors of diabetes, type 2|
|Harry Keen Fellow and Clinical Senior Lecturer||β cells, Type 1 diabetes, C-peptide, translational research, autoantibodies, autoimmune disease, Type 1 diabetes, Genetic risk score, T1D GRS, Extremely early onset type 1 diabetes|