Project ideas for LSI Studentships 2020/21

The Living Systems Institute is pleased to announce studentship opportunities for September 2020 intake, these studentships are available on a part-time or a full-time basis.  

LSI wishes to recruit the best and most imaginative students from across the full range of disciplines working within LSI - Biologists, Physicists, Mathematicians, Computational Scientists and Engineers using cutting-edge technologies. 

We welcome ideas for interdisciplinary research projects or you could consider one of our examples from the list below.  Noting the academics listed in italics below the project title are probable supervisors at this stage and are subject to change.  

Probing Quantum Optical Effects of a Micro Brain with Nano and Quantum Biosensors
Frank Vollmer, Gaspar Jekely, Jolly Xavier

Directed evolution of Cas endonucleases using droplet microfluidics and single-molecule sensing for next-generation gene therapies'.
Fabrice Gielen, Frank Vollmer, Akshay Bhinge

A chemically inducible dimerisation system to monitor and control protein-protein interactions in live cells using super-resolution microscopy
Christian Soeller, Steven West and Steffen Scholpp

Using concepts from physics to optimise directed co-evolution of functional enzyme pairs in the laboratory
Wolfram Moebius, Nic Harmer

Biophysical dissection of enzyme function at the single molecule level
Nic Harmer, Frank Vollmer, JJ Phillips

 

Diagnosis of blood cancers with on chip phenotypic profiling
Catalin Chimerel, Benjamin Housden

Using single molecule imaging, Cryo-electron microscopy and bioengineering platforms to study cell division and cancer
James Wakefield, Christian Soeller, Bertram Daum, Vicki Gold and Remy Chait

Bioengineering lineage segregation from human naïve stem cells to recapitulate early human development
Austin Smith, Stefano Pagliara

Developing a next-generation screening platform for new and effective antibiotic drugs
Benjamin Housden, Stefano Pagliara, Nic Harmer

Whole-body EM reconstruction and computational modelling of muscle dynamics in a marine larva
Gáspár Jékely, Krasimira Tsaneva-Atanasova

Quantitative analysis of Wnt pathway components at cytoneme contact sites in the living zebrafish embryo by super-resolution microscopy
Steffen Scholpp, Christian Soeller, Kyle Wedgwood

Investigating neuromuscular junction collapse in motor neuron disease using patient-derived stem cells, microfluidics and super-resolution microscopy.
Akshay Bhinge, Christian Soeller, Fabrice Gielen

Investigating the self-assembly of microbial cell wall proteins by complementary single molecule sensing, cryo electron microscopy and high-resolution light microscopy
Bertram Daum, Frank Vollmer, Christian Soeller

Tracking structural and nuclear changes in host cells induced by viral infection using a systems biology approach
Vicki Gold, Adam Monier

Using CRISPR-Cas9 genome editing and single molecule imaging to trace RNA fate – one molecule at a time
Steven West and Christian Soeller

The quantum robin: How cryptochrome protein senses Earth’s magnetic field
J.J. Phillips, Daniel Kattnig (LSI, Physics)
External co-supervisor Prof. R. Muheim (Univ. Lund)

Multiscale coordination of cilia: biophysical and neuronal mechanisms of wave propagation in ciliary arrays
Kirsty Wan, Gáspár Jékely

Computer-in-the-loop interrogation of dynamic behaviors on cellular networks"
Remy Chait, Kyle Wedgwood

Tackling antibiotic resistance by measuring and modelling the uptake of viruses and antibiotics in single cells
Stefano Pagliara, Krasimira Tsaneva-Atanasova, David Richards

Combining omics, synthetic and structural biology to functionally characterise viral dark matter and determine its role in host cell manipulation”
Adam Monier, Vicki Gold

Deciphering the mechanism of microbial motility from ångströms to micrometres, from femtoseconds to milliseconds, from bioimaging to molecular simulations and beyond
Daniel Kattnig, Bertram Daum, Wolfram Moebius, Vicki Gold

Modelling the mechanisms that allow bacteria to change shape in response to the environment
David Richards and Stefano Pagliara

Charting the routes of functional switching of glycogen phosphorylase: a combined mathematical and experimental approach.
Kyle Wedgwood, JJ Phillips

Spatiotemporal dynamics of microsporidian infection investigated by cross-scale bioimaging and mathematical modelling
Bryony Williams, Kirsty Wan, Bertram Daum

Protein choreography at high spatiotemporal resolution: modelling the dynamics of enzyme catalysis."
Marc Goodfellow, J.J. Phillips

Evolutionary analysis of male-specific reproductive traits in hermaphroditic nematodes using comparative genomics, mass spectrometry, and cryo electron microscopy
Cameron Weadick, JJ Phillips and Bertram Daum

From cells to microbial communities: using synthetic and quantitative approaches to manage antibiotic resistance
Ivana Gudelj, Tobi Bergmiller, Remy Chait and Rob Beardmore

More detail on the funding and how to apply is available here