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Dr Brandon Invergo

Dr Brandon Invergo

Research Fellow

 

Overview

My research is generally in the area of evolutionary systems biology, wherein I am interested in the structure, dynamics and evolution of intracellular-protein signaling networks.  In particular, I focus on how natural selection acts on pathway-level signaling dynamics. For example, how evolvable are non-linear dynamic traits that are determined by the interactions of multiple proteins? How significantly do signaling dynamics vary between individuals, populations, or species? Where has natural selection produced unusually fast/slow dynamics? At what point do altered dynamics become dysregulation and disease?  Together, this requires: a) measuring signaling processes, b) reconstructing signaling pathways and analyzing them through mathematical models, c) modeling molecular evolutionary histories, and d) performing comparative analyses of protein signaling.

View my profile on the Mathematics website.

Research

Publications

Key publications | Publications by category | Publications by year

Key publications


Invergo BM, Brochet M, Yu L, Choudhary J, Beltrao P, Billker O (2017). Sub-minute Phosphoregulation of Cell Cycle Systems during Plasmodium Gamete Formation. Cell Rep, 21(7), 2017-2029. Abstract.  Author URL.
Invergo BM, Montanucci L, Bertranpetit J (2015). Dynamic sensitivity and nonlinear interactions influence the system-level evolutionary patterns of phototransduction proteins. Proc Biol Sci, 282(1820). Abstract.  Author URL.
Invergo BM, Dell'Orco D, Montanucci L, Koch K-W, Bertranpetit J (2014). A comprehensive model of the phototransduction cascade in mouse rod cells. Mol Biosyst, 10(6), 1481-1489. Abstract.  Author URL.

Publications by category


Journal articles

More KR, Kaur I, Gianetto QG, Invergo BM, Chaze T, Jain R, Huon C, Gutenbrunner P, Weisser H, Matondo M, et al (In Press). Phosphorylation-Dependent Assembly of a 14-3-3 Mediated Signaling Complex During Red Blood Cell Invasion by Plasmodium falciparum Merozoites.  Abstract.
Invergo BM, Petursson B, Bradley D, Giudice G, Petsalaki E, Beltrao P (In Press). Proteome-wide inference of protein kinase regulatory circuits.  Abstract.
Invergo BM, Brochet M, Yu L, Choudhary J, Beltrao P, Billker O (In Press). Sub-minute phosphoregulation of cell-cycle systems during Plasmodium gamete formation.  Abstract.
Invergo BM, Beltrao P (2018). Reconstructing phosphorylation signalling networks from quantitative phosphoproteomic data. Essays Biochem, 62(4), 525-534. Abstract.  Author URL.
Invergo BM, Brochet M, Yu L, Choudhary J, Beltrao P, Billker O (2017). Sub-minute Phosphoregulation of Cell Cycle Systems during Plasmodium Gamete Formation. Cell Rep, 21(7), 2017-2029. Abstract.  Author URL.
Fern├índez-Sampedro MA, Invergo BM, Ramon E, Bertranpetit J, Garriga P (2016). Functional role of positively selected amino acid substitutions in mammalian rhodopsin evolution. Sci Rep, 6 Abstract.  Author URL.
Invergo BM, Montanucci L, Bertranpetit J (2015). Dynamic sensitivity and nonlinear interactions influence the system-level evolutionary patterns of phototransduction proteins. Proc Biol Sci, 282(1820). Abstract.  Author URL.
Hodson N, Invergo B, Rayner JC, Choudhary JS (2015). Palmitoylation and palmitoyl-transferases in Plasmodium parasites. Biochem Soc Trans, 43(2), 240-245. Abstract.  Author URL.
Invergo BM, Dell'Orco D, Montanucci L, Koch K-W, Bertranpetit J (2014). A comprehensive model of the phototransduction cascade in mouse rod cells. Mol Biosyst, 10(6), 1481-1489. Abstract.  Author URL.
Colombo M, Laayouni H, Invergo BM, Bertranpetit J, Montanucci L (2014). Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes. Evolution, 68(2), 605-613. Abstract.  Author URL.
Invergo BM, Montanucci L, Laayouni H, Bertranpetit J (2013). A system-level, molecular evolutionary analysis of mammalian phototransduction. BMC Evol Biol, 13 Abstract.  Author URL.
Invergo BM, Montanucci L, Koch K-W, Bertranpetit J, Dell'orco D (2013). Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling. Cell Commun Signal, 11(1). Abstract.  Author URL.
Talevich E, Invergo BM, Cock PJA, Chapman BA (2012). Bio.Phylo: a unified toolkit for processing, analyzing and visualizing phylogenetic trees in Biopython. BMC Bioinformatics, 13 Abstract.  Author URL.
Dall'Olio GM, Marino J, Schubert M, Keys KL, Stefan MI, Gillespie CS, Poulain P, Shameer K, Sugar R, Invergo BM, et al (2011). Ten simple rules for getting help from online scientific communities. PLoS Comput Biol, 7(9). Author URL.
Oostra V, de Jong MA, Invergo BM, Kesbeke F, Wende F, Brakefield PM, Zwaan BJ (2011). Translating environmental gradients into discontinuous reaction norms via hormone signalling in a polyphenic butterfly. Proc Biol Sci, 278(1706), 789-797. Abstract.  Author URL.
Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, Balannik V, McDearmon EL, Omura C, Lumayag S, Invergo BM, Glawe B, et al (2007). Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse. Vis Neurosci, 24(1), 111-123. Abstract.  Author URL.
Pinto LH, Invergo B, Shimomura K, Takahashi JS, Troy JB (2007). Interpretation of the mouse electroretinogram. Doc Ophthalmol, 115(3), 127-136. Abstract.  Author URL.
Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, McDearmon EL, Fenner D, Lumayag SL, Omura C, Andrews AW, Baker M, et al (2005). Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse. Vis Neurosci, 22(5), 619-629. Abstract.  Author URL.

Conferences

Fernandez-Sampedro MA, Ramon E, Invergo BM, Bertranpetit J, Garriga P (2015). Molecular characterization of specific positively selected sites in mammalian visual pigment evolution.  Author URL.
Maddox DM, Vessey KA, Yarbrough GL, Invergo BM, Cantrell DR, Inayat S, Balannik V, Hicks WL, Hawes NL, Byers S, et al (2008). Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses.  Abstract.  Author URL.

Publications by year


In Press

More KR, Kaur I, Gianetto QG, Invergo BM, Chaze T, Jain R, Huon C, Gutenbrunner P, Weisser H, Matondo M, et al (In Press). Phosphorylation-Dependent Assembly of a 14-3-3 Mediated Signaling Complex During Red Blood Cell Invasion by Plasmodium falciparum Merozoites.  Abstract.
Invergo BM, Petursson B, Bradley D, Giudice G, Petsalaki E, Beltrao P (In Press). Proteome-wide inference of protein kinase regulatory circuits.  Abstract.
Invergo BM, Brochet M, Yu L, Choudhary J, Beltrao P, Billker O (In Press). Sub-minute phosphoregulation of cell-cycle systems during Plasmodium gamete formation.  Abstract.

2018

Invergo BM, Beltrao P (2018). Reconstructing phosphorylation signalling networks from quantitative phosphoproteomic data. Essays Biochem, 62(4), 525-534. Abstract.  Author URL.

2017

Invergo BM, Brochet M, Yu L, Choudhary J, Beltrao P, Billker O (2017). Sub-minute Phosphoregulation of Cell Cycle Systems during Plasmodium Gamete Formation. Cell Rep, 21(7), 2017-2029. Abstract.  Author URL.

2016

Fern├índez-Sampedro MA, Invergo BM, Ramon E, Bertranpetit J, Garriga P (2016). Functional role of positively selected amino acid substitutions in mammalian rhodopsin evolution. Sci Rep, 6 Abstract.  Author URL.

2015

Invergo BM, Montanucci L, Bertranpetit J (2015). Dynamic sensitivity and nonlinear interactions influence the system-level evolutionary patterns of phototransduction proteins. Proc Biol Sci, 282(1820). Abstract.  Author URL.
Fernandez-Sampedro MA, Ramon E, Invergo BM, Bertranpetit J, Garriga P (2015). Molecular characterization of specific positively selected sites in mammalian visual pigment evolution.  Author URL.
Hodson N, Invergo B, Rayner JC, Choudhary JS (2015). Palmitoylation and palmitoyl-transferases in Plasmodium parasites. Biochem Soc Trans, 43(2), 240-245. Abstract.  Author URL.

2014

Invergo BM, Dell'Orco D, Montanucci L, Koch K-W, Bertranpetit J (2014). A comprehensive model of the phototransduction cascade in mouse rod cells. Mol Biosyst, 10(6), 1481-1489. Abstract.  Author URL.
Colombo M, Laayouni H, Invergo BM, Bertranpetit J, Montanucci L (2014). Metabolic flux is a determinant of the evolutionary rates of enzyme-encoding genes. Evolution, 68(2), 605-613. Abstract.  Author URL.

2013

Invergo BM, Montanucci L, Laayouni H, Bertranpetit J (2013). A system-level, molecular evolutionary analysis of mammalian phototransduction. BMC Evol Biol, 13 Abstract.  Author URL.
Invergo BM, Montanucci L, Koch K-W, Bertranpetit J, Dell'orco D (2013). Exploring the rate-limiting steps in visual phototransduction recovery by bottom-up kinetic modeling. Cell Commun Signal, 11(1). Abstract.  Author URL.

2012

Talevich E, Invergo BM, Cock PJA, Chapman BA (2012). Bio.Phylo: a unified toolkit for processing, analyzing and visualizing phylogenetic trees in Biopython. BMC Bioinformatics, 13 Abstract.  Author URL.

2011

Dall'Olio GM, Marino J, Schubert M, Keys KL, Stefan MI, Gillespie CS, Poulain P, Shameer K, Sugar R, Invergo BM, et al (2011). Ten simple rules for getting help from online scientific communities. PLoS Comput Biol, 7(9). Author URL.
Oostra V, de Jong MA, Invergo BM, Kesbeke F, Wende F, Brakefield PM, Zwaan BJ (2011). Translating environmental gradients into discontinuous reaction norms via hormone signalling in a polyphenic butterfly. Proc Biol Sci, 278(1706), 789-797. Abstract.  Author URL.

2008

Maddox DM, Vessey KA, Yarbrough GL, Invergo BM, Cantrell DR, Inayat S, Balannik V, Hicks WL, Hawes NL, Byers S, et al (2008). Allelic variance between GRM6 mutants, Grm6nob3 and Grm6nob4 results in differences in retinal ganglion cell visual responses.  Abstract.  Author URL.

2007

Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, Balannik V, McDearmon EL, Omura C, Lumayag S, Invergo BM, Glawe B, et al (2007). Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse. Vis Neurosci, 24(1), 111-123. Abstract.  Author URL.
Pinto LH, Invergo B, Shimomura K, Takahashi JS, Troy JB (2007). Interpretation of the mouse electroretinogram. Doc Ophthalmol, 115(3), 127-136. Abstract.  Author URL.

2005

Pinto LH, Vitaterna MH, Shimomura K, Siepka SM, McDearmon EL, Fenner D, Lumayag SL, Omura C, Andrews AW, Baker M, et al (2005). Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse. Vis Neurosci, 22(5), 619-629. Abstract.  Author URL.

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