The Sir Henry Wellcome Building for Mood Disorders Research

The Mood Disorders Centre (MDC) was established as a partnership between the University of Exeter and the NHS to address key priorities in understanding and treating depression including (a) improving the efficacy of psychological interventions; (b) reducing the high rates of relapse and recurrence; (c) finding ways to make effective interventions widely available and accessible, given the high lifetime prevalence rates of depression (10-20%) and the limited number of therapists. Its vision is to deliver world-class research that develops new understanding of the psychological mechanisms underlying  mood disorders, translates this knowledge into more efficacious psychological interventions, improves the accessibility of evidence-based treatments for depression, and provides innovative programmes that train the next generation of clinical researchers, clinical practitioners and leaders.

The Sir Henry Wellcome Building for Mood Disorders Research is the result of a £3.6 million Capital Award from the Wellcome Trust and is dedicated to the improvement of the understanding and treatment of mood disorders. This state-of-the art, fit-for-purpose built clinical research facility houses individual and group treatment rooms, with built-in audiovisual recording, plus office and meeting space for clinical research. The Capital Award has also renovated a significant part of the Washington Singer Building on the University of Exeter’s Streatham Campus including a new biobehavioural laboratory with virtual reality environments, multichannel EEG and peripheral physiology and eye tracking facilities. This new facility and the associated ongoing relationship with the Wellcome Trust consolidates the position of the Mood Disorders Centre and the University of Exeter as a UK and international leader in basic and translational clinical research to improve the psychological understanding of mood disorders and to develop and evaluate new psychosocial interventions.

Examplar publications include:


Caseras, X., Lawrence, N. S., Murphy, K., Wise, R. G., & Phillips, M. L. (2013). Ventral striatum activity in response to reward: differences between bipolar I and II disorders. American Journal of Psychiatry, 170(5), 533-541.

Dickson, J. M., & Moberly, N. J. (2013). Reduced Specificity of Personal Goals and Explanations for Goal Attainment in Major Depression. PloS one, 8(5), e64512.

Dunn, B. D., Evans, D., Makarova, D., White, J., & Clark, L. (2012). Gut feelings and the reaction to perceived inequity: The interplay between bodily responses, regulation, and perception shapes the rejection of unfair offers on the ultimatum game. Cognitive, Affective, & Behavioral Neuroscience, 12(3), 419-429.

Norman L, Lawrence N, Iles A, Benattayallah A, Karl A (2015). Attachment-security priming attenuates amygdala activation to social and linguistic threat. Social Cognitive and Affective Neuroscience, 10, 832-839.

O'Mahen, HA, Karl A, Moberly N, Fedock G (2015). The association between childhood maltreatment and emotion regulation: Two different mechanisms contributing to depression?. Journal of Affective Disorders, 174, 287-295.

Psychogiou, L., & Parry, E. (2013). Why do depressed individuals have difficulties in their parenting role?. Psychological medicine, 1-3.

Ramchandani, P., & Psychogiou, L. (2009). Paternal psychiatric disorders and children’s psychosocial development. Lancet, 374, 646-653

Steinacher, A., & Wright, K. A. (2013). Relating the Bipolar Spectrum to Dysregulation of Behavioural Activation: A Perspective from Dynamical Modelling. PloS one, 8, e63345.

Watkins, E. R., & Nolen-Hoeksema, S. (2014). A habit-goal framework of depressive rumination. Journal of Abnormal psychology, 123, 24.

Williams MJ, Dalgleish T, Karl A, Kuyken W (2014). Examining the factor structures of the five facet mindfulness questionnaire and the self-compassion scale. Psychological Assessment, 26, 407-418.


O’Mahen, H.A., Woodford, J., Richards, D., Wilkinson, E., McKinley, J., Warren, F., & Taylor, R.S. (2014). Netmums: A Phase II Randomized Controlled Trial of a Guided Internet Behavioral Activation Treatment for Postpartum Depression. Psychological Medicine, 44, 1675-1689.

O'Mahen, H., Himle, J. A., Fedock, G., Henshaw, E., & Flynn, H. (2013). A pilot randomized controlled trial of cognitive behavioral therapy for perinatal depression adapted for women with low incomes. Depression and anxiety, 30(7), 679-687.

Kuyken, W., Byford, S., Taylor, R.S., Watkins, E.R., Holden, E., White, K., Barrett, B., Byng, R., Evans, A., Mullan, E., & Teasdale, J.D. (2008). Mindfulness-based Cognitive therapy to prevent relapse in recurrent depression. Journal of Consulting and Clinical Psychology, 76, 966-978.

Kuyken, W., Hayes, R., Barrett, B., Byng, R., T Dalgleish, T., Kessler, D., ...Byford, S. (2015). Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive relapse or recurrence (PREVENT): a randomised controlled trial. The Lancet 386, 63-73

Watkins, E. R., Taylor, R. S., Byng, R., Baeyens, C., Read, R., Pearson, K., ... & Hennessy, S. (2012). Guided self-help concreteness training as an intervention for major depression in primary care: a Phase II randomized controlled trial. Psychological medicine, 42(7), 1359.

Watkins, E.R., Mullan, E.G., Wingrove, J., Rimes, K., Steiner, H., Bathurst, N., Eastman, E., & Scott, J. (2011, July 21 on-line publication). Rumination-focused cognitive behaviour therapy for residual depression: phase II randomized controlled trial. British Journal of Psychiatry, 199, 317-322.


Crane, R. S., & Kuyken, W. (2013). The implementation of mindfulness-based cognitive therapy: Learning from the UK health service experience. Mindfulness, 4(3), 246-254.

O’Mahen, H.A. Woodford, J., McKinley, J., Warren, F., Lynch, T.,  & Taylor, R.S. (2013). Internet-based Behavioral Activation Treatment for Postnatal Depression (Netmums): A Randomized Controlled Trial. Journal of Affective Disorders. 150, 814-822.