IBCS Seminar - Andrea Caporali - University of Edinburgh

Vascular signalling in post-ischaemic angiogenesis: from microRNAs to autophagy-mediated mechanisms

An Institute of Biomedical and Clinical Science seminar
Date16 February 2022
Time15:00
PlaceThis event will be online by Zoom

Link to join can be found under the Abstract description

We are pleased to welcome Andrea Caporali to present at the next IBCS Seminar

Andrea obtained his PhD in the laboratory of Prof Costanza Emanueli at University of Bristol in 2006, where he acquired expertise in the research of cardiovascular and translational medicine. This was following successful research training in Italy (University of Modena) and Canada (University of Manitoba). At the University of Bristol, Andrea have contributed to demonstrate the mechanisms driving endothelial impairment in diabetes. This has further inspired him to investigate the deregulation of microRNAs in the diabetes-induced microvascular diseases as postdoctoral fellow in Emanueli laboratory from 2009. In 2012, Andrea was awarded of the British Heart Foundation Intermediate Fellowship at University of Bristol. In 2013, Andrea moved to University of Edinburgh by securing the prestigious tenure track programme Chancellor’s Fellowship in addition to the BHF Intermediate Fellowship. During the last eight years, Andrea adopted a variety of cellular and pre-clinical models to characterize vascular signalling behind ECs dysfunction and try to revert it by taking a drug or gene therapy approach. 


Abstract

After the onset of ischaemia, hypoxia-related pathways, immunoinflammatory balance, as well as changes in hemodynamical forces within vascular wall trigger all the processes regulating vascular homeostasis to establish a functional vascular network in ischaemic zones. In patients with ischemic diseases and comorbidities, most of the cellular and molecular mechanisms involved in the activation of vessel growth and vascular remodelling are markedly compromised. Thus, the identification and characterization of novel genes/regulatory pathways to better understand the process behind vascular repair is therefore crucial. Those mechanisms that regulate EC function are reputed targets to focus on in the future when aiming to promote vascular regeneration post-injury. In his lab, they use a combination of the cutting-edge techniques, including CLIP-seq, RNA-seq and endothelial specific knock-out mice to identify and characterise new vascular targets. For this talk, Andrea will focus on the characterization of miR-503 as mediator of endothelial cells- pericytes communication during ischaemia and, how from the analysis of miR-503 targets in endothelial cells, they have explored the contribution of autophagy to vascular disease.

https://Universityofexeter.zoom.us/j/92873935036?pwd=NHBBYVJTMVNST3VpQjBIc1hxT09oZz09

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