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IBCS Seminar Series

'Targeting the glomerular vasculature as a treatment for diabetic nephropathy'

An Institute of Biomedical and Clinical Science seminar
Date30 January 2019
Time15:00 to 16:30
PlaceNorth Cloisters 12

Speaker: Dr Luigi Gnudi, Professor of Diabetes and Metabolic Medicine, Kings College London

Professor Gnudi’s research focuses mainly on mechanisms of glomerular injury initiated by metabolic, haemodynamic, immunological, and oxidative insults. Loss of glomerular vascular permselectivity, marked by leakage of protein into the urinary space, is a key first step in many clinical conditions which induce vessel wall injury. Proteinuria is a recognised marker of renal disease and represents generalised vascular damage. Our programme utilises in vitro (cell culture), ex vivo (kidney biopsies, peripheral circulating progenitor endothelial cells), and in vivo (animal model of proteinuria, transgenics) research approaches, and provides an ideal setting for integrated research. The Unit is funded by government agencies (BBSRC, MRC), charities (Diabetes UK, NKRF, EFSD), and industry.

Luigi Gnudi obtained his MD with Honours from the University of Parma (Italy) in 1988. He subsequently joined the residency programme at the School of Diabetes and Endocrinology at the University of Padua-Italy (1989-1993). During 1993-1995, he worked as a postdoctoral fellow with Prof Barbara B Kahn at Beth Israel Hospital, Harvard Medical School in Boston. In 1998 he obtained a PhD in Endocrinological Sciences from the University of Milan. He became a Fellow of both the Royal College of Physicians and the American Society of Nephrology in 2005. Dr Gnudi joined the Unit for Metabolic Medicine (within the Department of Diabetes, Endocrinology and Internal Medicine) in 1997 as Senior Lecturer and was promoted to Professor of Diabetes and Metabolic Medicine in 2011. He became Head of the Unit for Metabolic Medicine in 2010. Prof Gnudi is an Honorary Consultant Physician in Diabetes, Endocrinology and Metabolic Medicine at Guy's and St Thomas' Hospital NHS Foundation Trust.

 


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