IBCS Wednesday seminar 3rd April

‘Kappa opioid receptors – a target for novel antidepressants’

An Institute of Biomedical and Clinical Science seminar
Date3 April 2019
Time15:00 to 16:30
PlaceG18

Dr Sarah Bailey University of Bath Department of Pharmacy and Pharmacology

Abstract/interests

Depression is estimated to affect 1 in 6 UK adults at any one time. The likelihood of developing depression is influenced by genetic factors and by lifetime experience and environmental factors. However, the molecular basis of these diseases is not well understood.

In Dr Sarah Bailey’s lab a combination of behavioural, electrophysiological and molecular techniques are used to learn more about the molecular mechanisms involved in the response to stress and the development of depression. They are particularly focusing on the role of central opioid receptors in the regulation of stress responses, anhedonia and mood. In collaboration with Prof Husband's group, Dr Sarah Bailey examines the role of kappa opioid receptors in the response to stress and develops novel kappa opioid receptor ligands with antidepressant potential. They are also investigating the influence of age and sex on the response to stress and KOR activation.


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