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Award details

University of Exeter funding: BBSRC SWBio DTP PhD studentship

Investigating the time course of vitamin D storage in human adipose and skeletal muscle and the relationship to skeletal muscle protein synthesis, PhD in Sport and Health Sciences Studentship (BBSRC SWBio DTP funded) Ref: 3983

About the award

Supervisors

Lead Supervisor

Dr Raquel Revuelta Iniesta, College of Life and Environmental Sciences, University of Exeter

Additional Supervisors

Prof Francis Stephens, College of Life and Environmental Sciences, University of Exeter

Location:  St Luke's Campus, University of Exeter, Exeter, Devon

The SWBio DTP is one of the 12 Doctoral Training Partnerships funded by the BBSRC to provide PhD training in areas of their strategic relevance.  The SWBio DTP is a consortium comprising the Universities of Bristol (lead), Bath, Cardiff, Exeter, and Rothamsted Research. Together, these institutions present a distinctive cadre of bioscience research staff and students with established international, national and regional networks and widely recognised research excellence.

The aim of this DTP is to produce highly motivated and excellently trained postgraduates in the BBSRC priority areas of Agriculture & Food Security (AFS) and World-Class Underpinning Bioscience (WCUB). These are growth areas of the biosciences and for which there will be considerable future demand.

The award:

This project is one of a number that are in competition for funding from the South West Biosciences Doctoral Training Partnership (SWBio DTP)

Project Description:

Healthy adults maintain muscle tissue by continuously building up and breaking down muscle proteins throughout the day. This happens due to the daily influences of nutrition and physical activity. Specifically, recent studies have shown that vitamin D is essential for maintaining muscle mass by activating anabolic pathways (in response to anabolic stimuli) involved in muscle protein synthesis (MPS). Although, various candidate molecules and physiological pathways have been identified in vitro and animal models, it is unclear whether these findings translate into in vivo human models. The main storage site for vitamin D in humans is adipose tissue and we (Prof Thompson) have preliminary data demonstrating that it can be released upon exercise, which is another anabolic stimulus for skeletal muscle. Interestingly, animal studies indicate that up to 20% of vitamin D is also stored in human skeletal cells and epidemiological data from the UK suggest that despite insufficient sunlight in winter to synthesise vitamin D in the skin, a significant proportion of a population resident in Scotland, maintained blood vitamin D concentration above 50 nmol/L (sufficiency).

The PhD student will test the hypothesis that vitamin D supplementation increases the human MPS response to anabolic stimuli (feeding and exercise) by stimulating the mTOR pathway. Furthermore, the PhD student will also
investigate the temporal nature of vitamin D storage in human adipose and skeletal muscle during vitamin D supplementation and whether vitamin D released from adipose tissue is taken up by skeletal muscle.

This research project will be conducted within the University of Exeter Nutritional Physiology Group
(http://sshs.exeter.ac.uk/research/integrativephysiology/nutritionalphysiology/) and spend a period of time at the University of Bath, Department for Health, learning necessary skills for investigating adipose tissue vitamin D turnover.

This project will provide the student with an excellent cross-disciplinary skill set utilising techniques such in vivo nutritional physiology techniques necessary to address the hypothesis of this study. These include, direct
measures of MPS using stable isotope, muscle and adipose biopsy sampling, arterio-venous balance, and ex vivo sample analysis including gene array and protein signalling.

Eligibility

To be eligible for a fully-funded studentship, you must meet both the academic and residence criteria. 

A fully-funded four year SWBio DTP studentship will cover

•    a stipend* at the standard Research Council UK rate; currently £15,285 per annum for 2020-2021
•    research and training costs
•    tuition fees (at the standard Research Councils UK rate)
•    additional funds to support fieldwork, conferences and a 3-month internship

Please refer to the regulations or Annex 1 of the Research Council Training Grant Guide to confirm that you meet the residence criteria for a fully-funded studentship.  Any further queries in relation to residency must be directed to the institution that you are applying to.

* An enhanced stipend is available for students with a recognised veterinary degree qualification (£23,164 per annum for 2019-2020). There may also be enhanced stipends associated with projects that have a CASE partner (CASE projects are highlighted as *CASE in the project lists).

Residence criteria

UKRI have recently updated their policy for funded studentships which starts from the 2021/2022 academic year.
IMPORTANT: Please refer to the UKRI Full Eligibility Criteria alongside the information provided below.

Home students

Fully-funded studentships are available for Home students.  To be classed as a Home student, candidates must meet the following criteria:
• Be a UK National (meeting residency requirements), or
• Have settled status, or
• Have pre-settled status (meeting residency requirement) or,
• Have indefinite leave to remain or enter

International students

If you do not meet the above criteria, you will be classed as an International student.
A limited number (up to 30%) of UKRI fully-funded studentships are available through the SWBio DTP, that applicants who would be classed as an International student are eligible for.  Please apply through our normal application route.

Entry requirements

Applicants should have obtained, or be about to obtain, a First or Upper Second Class UK Honours degree, or the equivalent qualifications gained outside the UK, in an appropriate area of science or technology.  Applicants with a Lower Second Class degree will be considered if they also have Masters degree or have significant relevant non-academic experience.

In addition, due to the strong mathematical component of the taught course in the first year and the quantitative emphasis in our projects, a minimum of a grade B in A-level Maths or an equivalent qualification or experience is required.

If English is not your first language you will need to have achieved at least 6.5 in IELTS and no less than 6.5 in any section by the start of the project.  Alternative tests may be acceptable, please see  http://www.bristol.ac.uk/study/language-requirements/profile-c/.

Equivalent qualifications/experience

  • Physics A-level (grade B and above)
  • Undertaking units as part of your degree that have a significant mathematical component*

*Significant mathematical component examples include; maths, statistics, bioinformatics.

Applicants must ensure they highlight their Maths background within their application and to upload any supporting evidence.

How to apply

Please be aware you will be asked to upload the following documents:

  • CV
  • Letter of application outlining your academic interests, prior research experience and reasons for wishing to undertake the project.  Please indicate your preferred project choice if applying for multiple BBSRC SWBio DTP projects.
  • Transcript(s) giving full details of subjects studied and grades/marks obtained.  This should be an interim transcript if you are still studying.
  • Two academic referees - see information below about references.
  • If you are not a national of a majority English-speaking country you will need to submit evidence of your proficiency in English (see entry requirements above)

The closing date for applications is midnight on Monday, 7 December 2020. Interviews will be held at the University of Exeter between w/c 25 January - w/c 1st February 2021.

Reference information
You will be asked to name 2 referees as part of the application process, however we will not expect receipt of references until after the shortlisting stage. Your referees should not be from the prospective supervisory team.

If you are shortlisted for interview, please ensure that your two academic referees email their references to the pgr-recruitment@exeter.ac.uk, 7 days prior to the interview dates.  Please note that we will not be contacting referees to request references, you must arrange for them to be submitted to us by the deadline.

References should be submitted by your referees to us directly in the form of a letter. Referees must email their references to us from their institutional email accounts. We cannot accept references from personal/private email accounts, unless it is a scanned document on institutional headed paper and signed by the referee.

If you have any general enquiries about the application process please email pgrenquiries@exeter.ac.uk.

Project-specific queries should be directed to the primary supervisor.

Selection process:

Please note, the studentship selection process will take place in two stages:

1.     The project supervisors will consider your application and may invite you to visit for an informal interview. You can apply for more than one BBSRC SWBio DTP project, although supervisors may take into account your interest and commitment to their particular project.  If you apply for multiple projects, please indicate your preferred project choice in your letter of application.  Each application for an individual project will be considered separately by the project supervisors.

2.     After closure of applications, each supervisory team will then nominate their preferred applicant.  A shortlist will be selected from these nominations and shortlisted applicants will be invited for interview on a selection day at the University of Bristol.  Please note that nomination by a project supervisor therefore does not guarantee the award of a studentship.
 

Data Protection
During the application process, the University may need to make certain disclosures of your personal data to third parties to be able to administer your application, carry out interviews and select candidates.  These are not limited to, but may include disclosures to:

  •     the selection panel and/or management board or equivalent of the relevant programme,   
        which is likely to include staff from one or more other HEIs;
  •    administrative staff at one or more other HEIs participating in the relevant programme.

Such disclosures will always be kept to the minimum amount of personal data required for the specific purpose. Your sensitive personal data (relating to disability and race/ethnicity) will not be disclosed without your explicit consent.

Summary

Application deadline:7th December 2020
Value:Tuition fees and an annual stipend allowance at Research Council rates, currently £15,285 per year for 2020-21
Duration of award:per year
Contact: PGR Recruitment Office pgrenquiries@exeter.ac.uk