Independent Fellows

Ryan Ames

BBSRC Innovation Fellow 2018 - 2021

Research interests focus on how phenotype arises from complex systems, and generating accurate representations of cellular function using integrated interaction networks.

Area of expertise:

  • Systems biology

  • Evolutionary biology

  • Genome wide studies

  • Next generation sequence data analysis

  • Network analysis

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: r.ames@exeter.ac.uk

Phone: 01392 727473

You can also visit Ryan's personal website.

Yolanda Hill

MRC-funded UKRI Innovation Fellow 2017 - 2020

Yolanda is working with Professors Jonathan Fieldsend at the University of Exeter and John Terry at the University of Birmingham, Dr Glyn Thomas at the Bristol Heart Institute and industry partner Johnson & Johnson, on her project Cardiac Positioning System (CPS) - An automated navigation system to guide catheter ablation therapy.

Holding a Bachelor's degree in Biology with Psychology from Queen Mary University of London, Yolanda then went on to complete her PhD at King's College London in Computational Cardiac Electrophysiology, modelling reentrant electrical activation waves which cause ventricular arrhythmias. Notably, her work contributed to developing a novel strategy to guide cardiac ablation therapy to treat ventricular tachycardia arising from myocardial infarction.

Yolanda's current research builds on improving the treatment of ventricular tachycardia by refining the pace mapping technique used during ablation, to reduce the risk and increase success rates of the procedure. Her work focuses on implementing machine learning algorithms to indicate the location of infarct scar tissue and critical reentrant circuit sites from electrocardiogram data. Accurate identification of these areas of diseased tissue help to guide the delivery of successful ablation therapy to terminate ventricular tachycardia.

Charlie Jeynes

STFC Innovation Research Fellow 2018 - 2021

Charlie's research investigates topics in imaging biology, in particular using nanoparticles to improve resolution, quantitate and model features in human cells related to diseases and ageing.

Area of expertise:

  • Advanced microscopy (super resolution and elemental microprobes).

  • Image analysis.

  • Modelling.

  • Nanoparticle biomarkers.

  • Elemental analysis.

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: j.c.g.jeynes@exeter.ac.uk

Phone: 01392 727471

You can also visit Charlie's personal website.

David Richards

MRC Career Development Fellow 2018 - 2022

David's research research uses mathematical and computational modelling to try to understand processes in our immune systems. In particular he focuses on phagocytosis, the way that immune cells ingest large particles, such as bacteria, debris and dead cells. David’s work involves a multidisciplinary approach, combining spatio-temporal modelling and image analysis with micropipette experiments.

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: david.richards@exeter.ac.uk

Phone: 01392 727483

You can also visit David's personal website.

Jamie Walker

Medical Research Council Career Development Fellow 2016 - 2021

Dr Jamie Walker is a Medical Research Council Research Fellow with interests in complex dynamical processes in neuroscience and neuroendocrinology. Using a multidisciplinary approach, combining predictive mathematical modelling and analysis with experimental biology, Jamie is currently focused on understanding how the hypothalamic-pituitary-adrenal (HPA) axis regulates the pulsatile secretion of vital glucocorticoid hormones, and why the dynamics of this system changes in different physiological and pathological conditions. 

Address: Centre for Biomedical Modelling and Analysis, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: Jamie.Walker@exeter.ac.uk 

Phone: 01392 406816

Kyle Wedgwood

MRC Skills Development Fellow 2017 - 2020

Kyle's research addresses fundamental questions about the collective behaviour of biological networks, with a particular focus on diabetes and neuroscience.

The aim of his research is to investigate how the individual units within biological network act in concert to perform functional tasks, for example, regulating insulin secretion from networks of pancreatic beta cells to control blood glucose levels. Dysfunction of, or disruption to, these networks ultimately leads to diabetes. Through a multidisciplinary approaching, involving electrophysiology experiments and mathematical modelling, he hopes to better understand how to 'rescue' or improve network function following these insults, in order to highlight potential avenues for diabetes treatment.

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: k.c.a.wedgwood@exeter.ac.uk

Phone: 01392 727485

You can also visit Kyle's personal website.

Wessel Woldman

MRC Skills Development Fellow 2016 - 2020

Wes's central research focus is around applying mathematical techniques and computational models to clinical and health-care related problems with a strong focus on epilepsy and diabetes. Of particular interest is the dynamic behaviour of systems in the body, both in its healthy state, as well as in pathological states, and understanding how transitions between them occur and might be prevented.

Wessel develops and analyses mathematical models and interrogates clinical and experimental data, in order to discern differences between healthy controls and people with epilepsy which could potentially decrease misdiagnosis and improve the prognosis for people with epilepsy.

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: www201@exeter.ac.uk 

Phone: 01392 406816

Joana Viana

MRC-funded Rutherford Fund Fellow 2017 -2020

Joana's research focuses on investigating the epigenomic, transcriptomic and regulatory changes that occur in cell differentiation during vertebrate development. She is working with collaborators at the University of Exeter and industry partner Eli Lilly, on her project Genomic regulation of vertebrate development.

Epigenetic and gene expression changes during development play crucial roles in determining cell fate. Insults during this time can cause abnormalities in these mechanisms and lead to disorders later in life. Determining the genomic regions that undergo changes during early development is essential to understand the molecular mechanisms involved in development and multiple developmental disorders.

In her research, she combines cutting-edge sequencing methodologies and bioinformatics analysis to profile the genomic regulatory landscape of vertebrate development.