Matt Anderson - Industry Research Fellow

Matt completed his PhD in Complexity Sciences from the University of Bristol in 2017 and has since been part of the Translational Research Exchange @ Exeter (QBME) group, first as a PDRF and then as an Industrial RF from 2019. His research focuses on industrial and clinical collaboration, and spans the interface between mathematical modelling, machine learning classification (MLC) and cell/molecular biology in cancer, diabetes and Inflammatory Bowel Disease (IBD).

Current & recent projects:

  • Developing MLC algorithms to improve the efficiency of RNAi drug screening methods for cancer and a range of other diseases.

  • Applying MLC algorithms to identify clinically actionable factors that cause loss of drug response in IBD patients.

  • Implementing species distribution models and MLC algorithms for the advancement of industrial pest control methods.

  • Investigating the interactions between fatty acids and autophagy in diabetes using molecular methods and novel computer vision techniques.

  • Broadening invasive species distribution models without the loss of significant predictive power.

Research themes: machine learning classification; complex networks; cell & molecular biology; image analysis & computer vision; and spatio-temporal modelling.

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter EX4 4QD

Email: M.W.Anderson@exeter.ac.uk

Jehangir Cama - Industry Research Fellow

Jehangir completed an undergraduate BSc. (Hons.) Physics degree at St. Stephen's College, University of Delhi, before joining Trinity College, Cambridge to study Parts II and III of the Natural Sciences Tripos (Physics). He continued on at Trinity and at the Cavendish Laboratory in Cambridge for his PhD under the supervision of Prof. Ulrich Keyser, where he focused on understanding antibiotic transport across biomimetic membrane systems. This is of particular relevance for Gram-negative bacteria, whose double membrane cell envelope is a formidable permeability barrier that protects these cells from small molecule antibiotics. Understanding the physical processes governing Gram-negative drug permeation is a crucial challenge facing antibiotic developers, who are trying to counteract the alarming spread of antibiotic resistance in bacterial pathogens across the globe.  Jehangir continued this research as a PDRA in Prof. Keyser's laboratory, and was also a Research Fellow at Clare Hall, Cambridge.

Jehangir is also part of a multi-centre consortium, including the National Physical Laboratory, the STFC Hartree Centre, IBM Research, and the Universities of Cambridge and Exeter, that is developing a new pipeline of polypeptide antibiotics that circumvent the permeability barrier of Gram-negatives by directly attacking and lysing cell membranes.

Jehangir has expertise in the development of microfluidic technologies for biological and biomedical research. His current projects include:

  • Quantifying antibiotic accumulation label-free in Gram-negative bacterial cells in well-defined microenvironments.  Collaboration with Dr. Stefano Pagliara, Prof. Krasimira Tsaneva-Atanasova, Dr. Margaritis Voliotis and Dr. Jeremy Metz (LSI, Exeter), along with Prof. Matthew Cooper and Dr. Mark Blaskovich (University of Queensland).

  • Quantifying antibiotic accumulation across specific lipid and protein pathways in biomimetic lipid vesicles. Collaboration with Prof. Ulrich Keyser (Cambridge), Prof. Christopher Dowson (Warwick) and Prof. Mathias Winterhalter (Jacobs University, Bremen).

  • Developing assays to quantify the efficacy and selectivity of new polypeptide antibiotics on both vesicles and bacterial cells. Collaboration with Dr. Maxim Ryadnov (NPL), Prof. Ulrich Keyser (Cambridge), Dr. Stefano Pagliara (LSI, Exeter), IBM Research, the STFC Hartree Centre with further involvement from industry partners.   

  • Studying the biophysical aspects of indole signalling and its role in bacterial metabolism. Collaboration with Dr. David Summers (Genetics, Cambridge).

Jehangir joined the Living Systems Institute as an Industrial Research Fellow to build collaborations with pharmaceutical and biotechnology partners in the field of antibiotic testing and development in February 2019.

Research themes: Membrane transport, antibiotic resistance, microfluidics, label-free optical techniques, bacterial signalling.

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: j.cama@exeter.ac.uk

Jack Spencer - Industry Research Fellow

Jack was awarded a BSc in Mathematics from the University of Liverpool in 2012, before beginning his PhD in Applied Mathematics under the supervision of Prof. Ke Chen in the same department. He joined the Centre for Mathematical Imaging Techniques (CMIT), working on variational methods in computer vision, convex optimisation, and numerical methods.

After completing his PhD in 2016, Jack joined the newly formed EPSRC Liverpool Centre for Mathematics in Healthcare (LCMH) as a postdoctoral research associate. He worked closely with LCMH’s research partners, including Mirada Medical and Clatterbridge Cancer Centre, on interactive segmentation methods in 2D and 3D with applications including radiotherapy planning.

Jack works within the Translational Research Exchange at Exeter (TREE) as an industrial postdoctoral research fellow, where he is developing collaborations with new clinical and industrial partners. The work focuses on computer vision problems, using his experience with mathematical modelling at CMIT and LCMH, to create innovative approaches to important challenges in medical imaging.

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: j.a.spencer@exeter.ac.uk

David Whitehouse - Business Development Lead: Health Technologies

David works within the Innovation, Impact and Business Directorate as Business Development Lead: Health Technologies. He is the sub-theme lead for Medical Technologies within the Healthcare and Biotech theme and is primarily based at the Living Systems Institute (LSI).

David has 20+ years’ experience in the Healthcare Sector working across multiple therapy areas and technologies.  He has held commercial positions of increasing responsibility primarily in marketing & sales with Janssen-Cilag (J&J), Genzyme, Baxter and most recently with Baxter International as Commercial Marketing Director responsible for the renal portfolio across Europe based in Zurich, Switzerland.

David is tasked with developing new collaborations with external partners, supporting impact development and advising on translational research funding, and driving income generation across the University for the sub-theme.

Roger Killen - Royal Society Entrepreneur in Residence

Roger is a Royal Society Entrepreneur in Residence, a role in which he is seeking to accelerate the transition of University research into impactful commercial enterprise. He is hosted by Prof John Terry at the Living Systems Institute.

Roger is a serial entrepreneur. He founded The Learning Clinic (TLC) where he invented the category of electronic hospital observations, a category in which TLC (VitalPAC) are the clear global leader. Prior to founding TLC, Roger was co-founder of Dr Foster Ltd, which rapidly became the market leader for research into medical outcomes, and the number one hospital benchmarking company in the UK. He has been a serial entrepreneur since earning an MBA from Stanford Business School in California in 1990.