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IBCS Seminar

The role of ABCC5 in energy metabolism in man – how, why, where?

Professor Heidi de Wet – Associate Professor of Physiology - Oxford Center for Gene Function

Event details

Heidi de Wet studied Biochemistry at the Potchefstroom campus of the North-West University, South Africa and completed a DPhil at the University of Cape Town.  She spent her post-doctoral training in the laboratories of Profs Richard Callaghan and Frances Ashcroft at the University of Oxford where she was employed as a University Lecturer in the Department of Physiology, Anatomy and Genetics and Tutorial Fellow of St Catherine’s in 2013.  She works on ATP-binding cassette transporters and their role in metabolic health and disease. 

The ATP binding cassette exporter C5 (ABCC5) is a glutamate analogue transporter and has been shown to transport ~9 different glutamate metabolites using untargeted metabolomics screens, including the neurotransmitters NAAG (N-acetylaspartylglutamate) and NMDA (N-methyl-D-Aspartic acid).  Both these neurotransmitters regulate exocytosis events, and therefore excitability, in neurones through their action on NMDA receptors.