LSI Affiliates are Principal Investigators in the University of Exeter who have close links with LSI through collaborative projects, joint grants or co-supervised students.
My research interests include the mathematics and applications of nonlinear dynamical systems, especially synchronization problems, bifurcations, computational modelling, spatially extended systems and nonautonomous systems. The applications to living systems I am interested in include biophysical modelling (active transport and organelle dynamics in cell biology), cognition (perceptual rivalry, computational aspects of networks), molecular networks, functional dynamics in neural and biomedical systems and tipping points in nonautonomous systems.
My research focuses on how the interactions of filamentous fungal pathogens with their physical environment results in invasive growth behaviour. The ability to control the direction of filamentous growth in order to penetrate relevant substrates is fundamental across most environmental fungi but, in the context of human disease, the ensuing tissue damage leads to hyper-inflammation, organ failure and mortality. My group uses a number of biophysical approaches to elicit growth responses from fungal hyphae at the molecular and whole-cell levels. Live-cell imaging within micro-fabricated chambers enable us to track changes in the spatial distribution of protein complexes and correlate this with fungal morphology and behaviour in response to tip-contact, electric fields and the mechanical properties of the extracellular matrix.
My current work with LSI staff and Affiliates includes:
• Development of image analysis tools with David Richards
• Inference of spatial regulatory mechanisms through analysis of protein complex dynamics with Wolfram Moebius
• Building Microfluidics capacity with Stefano Pagliara, Tobias Bergmiller, Remi Chait and Jehangir Cama.
Professor Nigel Cairns, an internationally-recognized neuropathologist, is working with colleagues at LSI, Drs Vicki Gold and Betram Daum, to more fully characterize the atomic structure of misfolded proteins, the pathologic building blocks of most neurodegenerative diseases. Unravelling these misfolded proteins may reveal novel targets for therapeutic intervention where none currently exists.
Professor Nigel Cairns is also developing collaborations with Drs JJ Phillips and Daniel Kattnig.
Peter Challenor is a Professor in the Mathematics Department where he leads the Statistics and Data Science group. His interests include decision making with complex numerical models and uncertainty quantification for such models. Increasingly numerical models are being developed to explain and predict the behaviour of living systems. Such models may be derived from physical and biological principles and expressed as the solutions of sets of differential equations or they may derive from data via statistical and machine learning methods. In either case, if we are to use such models for real world decision making we need to know the quality of such models. One way to measure such quality is to estimate the uncertainty involved in the modelling and via comparison with real world data.
My research investigates the application of advanced photonics techniques to medical imaging. Specifically I am interested in the development of new microscopy tools that can improve the specificity and spatiotemporal resolution of biomedical image data. Current projects include the rapid acquisition of three-dimensional data sets of excitable tissues and the development of coherent optical methods for dye-free optical imaging. I am also interested in the development of quantitative methods in biomedical imaging, including the development of new calibration standards to place specific bounds on the accuracy of image data.
I obtained MSci (Physics) and PhD (optical engineering) degrees from the University of Cambridge, UK in 2003 and 2008 respectively. After working for a research-intensive Cambridge start-up for four years, I began postdoctoral research in fast scanning optical microscopy in the group of Prof Tony Wilson, University of Oxford in 2010. To broaden my experience I worked on a series of imaging-based projects as a Senior Engineer at Canon Research in Sydney, Australia. I returned to Oxford in 2014 to construct a remote focusing multiphoton microscope in the Department of Physiology in collaboration with Prof Gil Bub, Prof Ed Mann and Dr Rebecca Burton. I began a lectureship in the Biomedical Physics group in January 2016, becoming a Senior Lecturer in April 2020.
Dr Creaser's research focuses on developing and using tools from dynamical systems theory to understand problems in healthcare. She currently holds an MRC Skills Development Fellowship to identify patient-specific brain dynamics markers in Post-Traumatic Stress Disorder (PTSD) and Cognitive Treatment Response. She works closely with colleagues in the LSI to use mathematical and computational methods to analyse large scale brain recordings from people with depression and PTSD. Together with Professor Tsaneva-Atanasova, she developed a network modelling framework to capture and explain seizure onset patterns at multiple spatial scales including seizures captured by clinical scalp recordings and generated by in-vitro experiments.
My group works on the pathogenic interactions between fungal pathogens and the human host. Our main interest is understanding the structure and function of the fungal cell wall as the natural interface between the pathogen and its host. We are investigating the ligands of the wall that are important for immune recognition and the cell wall biosynthetic processes that can be used as targets the development of antifungal drugs and antifungal vaccines. My group is supported by a Wellcome Senior Investigator Award, two Wellcome Collaborative Awards and a number of joint awards with colleagues in the MRC-CMM and LSI.
Relationships with staff in the LSI:
- I am a co-applicant on a project called the Molecular Mechanic Initiative (MMI) supported by EPSRC Physics for Life grant led by Professor Frank Vollmer and team of co-investigators. This is using nanoparticle technologies and single molecule sensors to investigate fungal cell wall binding proteins.
- I am a co-applicant on BBSRC equipment grant award led by Professor Gaspar Jekely that funds cryo-fixation/ freeze-substitution equipment underpinning high resolution electron microscopy and tomography.
- I am working with Dr Caitlin Chimerel investigating the pharmacodynamics of AmBisome (and antifungal drug that is delivered in a liposomal formulation), using cavity enhanced absorption spectroscopy that has th potential to make single cell measurements of drug translocation.
- I am beginning to investigate how novel microfluidic methodologies can be applied to study fungus-drug interactions with a new team of LSI researchers.
"Francesca Palombo is an Associate Professor of Biomedical Spectroscopy at the School of Physics and Astronomy. Dr Palombo is a pioneer in optical elastography to study biomechanics on a subcellular scale. She was a postdoctoral research associate at Imperial College London and UEA before joining Exeter as a lecturer in 2013. She has a strong vibrational spectroscopy background which spans frequency-domain and time-resolved laser spectroscopy, imaging and microscopy techniques. Her core biomedical studies focus on disease detection, especially cancer and dementia, along with fundamental biochemistry and biophysics."
My research interests are in the area of membrane biophysics, focusing on the importance of the membrane physical properties in controlling and directing biological function in health and disease. I have more than 20 years’ experience in red cell research and model and artificial lipid membranes, including Langmuir lipid monolayers and synthetic lipid bilayers (vesicles), investigating their thermodynamics, viscoelasticity, microdomain mesoscopic structure, electrostatic potentials and morphology. Recent work from my laboratory includes studies of the effects of oxidative stress on membrane mechanical and electrical properties, and biochemical signalling originating from the red blood cell, the effects of membrane physical properties on the interactions between the plasma membrane and bacterial (pore-forming) toxins and immunotoxins, protein-lipid interactions in model systems, fatty acid transmembrane transport in mammalian cells, and the use of synchrotron-based methods to resolve the molecular organisation of model membranes. I have also worked in low Reynolds number hydrodynamics, statics and dynamics of wetting and self-propelling artificial swimmers.
I am a Senior Lecturer at the Institute of Biological and Clinical Science.
My research combines experiments, computation, and mathematics to understand the production of rhythmic activity in biological systems. Oscillations enable coordinated activity within biological systems, and disruptions in these oscillations can cause disease.
At the cellular level, I study the rhythmic electrical activity produced by neurones, cardiac myocytes, and endocrine pituitary cells.
At the network level, I study the oscillators that produce motor activity in the tadpole, and the dynamic coordination between these oscillators that results in swimming behaviour.
Collaborations with LSI staff:
— NetClamp: conducting neural network rhythms with mathematics (with Kyle Wedgwood).
— From model to action: using machine learning to predict how to stop arrhythmias (with Yolanda Hill and Christian Soeller).
I am a NERC funded Independent Research Fellow (Professor), working on the evolutionary ecology of host-parasite interactions. My lab studies how ecological variables drive the evolution of various immune strategies in bacteria, with an emphasis on CRISPR-Cas adaptive immune systems, and examines their coevolutionary consequences. Bacteria encode lots of different immune mechanisms, and their molecular basis has been studied in great detail, which makes them an ideal model system to study more generally how ecology drives the evolution of different defenses. These bacterial defense mechanisms include CRISPR-Cas, which I studied at the molecular level during the start of my scientific career, surface modification, restriction modification, abortive infection and prokaryotic Argonaute.
My primary research interest lies in understanding the developmental phenomenon of metamorphosis in marine animals. Many marine animals, including sponges, corals, jellyfish, shellfish, crustaceans, worms, sea urchins, starfish and sea squirts, have a life cycle which includes a free-swimming larval stage that must find the ideal location to settle down on the seafloor and undergo metamorphosis to an adult form. I use molecular biology approaches to study the sensory and neuroendocrine systems of marine invertebrate larvae to understand how they interact with their surrounding environment to navigate through the ocean and regulate the timing of their metamorphic transition. These larvae are crucial to the survival, connectivity and evolution of marine populations.
My background lies in marine biology and molecular biology. Following a BSc in Marine Biology at the University of Queensland, Brisbane, Australia, I carried out a BSc Hons research project investigating natural variation in gene expression during sea squirt larval development. During my PhD, I studied the interplay of genes and environment in the metamorphosis of tropical abalone, an emerging aquaculture species. I then joined the Max Planck Institute for Developmental Biology in Tübingen, Germany, as a postdoctoral researcher working on neuropeptide signalling in the life cycle of marine worms, sea anemones, jellyfish and placozoans. Following a move to the University of Exeter's new Living Systems Institute with my postdoctoral research lab in 2018, I was awarded a BBSRC David Phillips Fellowship in late 2019. Commencing May 2020, this fellowship allows me to build my independent research group in the Exeter Biosciences.