Affiliate and honorary members
The LSI is honoured to have the following affiliated and visiting academics:
LSI Affiliates are Principal Investigators in the University of Exeter who have close links with LSI through collaborative projects, joint grants or co-supervised students.
Professor Nigel Cairns, an internationally-recognized neuropathologist, is working with colleagues at LSI, Drs Vicki Gold and Betram Daum, to more fully characterize the atomic structure of misfolded proteins, the pathologic building blocks of most neurodegenerative diseases. Unravelling these misfolded proteins may reveal novel targets for therapeutic intervention where none currently exists.
Professor Nigel Cairns is also developing collaborations with Drs JJ Phillips and Daniel Kattnig.
My group works on the pathogenic interactions between fungal pathogens and the human host. Our main interest is understanding the structure and function of the fungal cell wall as the natural interface between the pathogen and its host. We are investigating the ligands of the wall that are important for immune recognition and the cell wall biosynthetic processes that can be used as targets the development of antifungal drugs and antifungal vaccines. My group is supported by a Wellcome Senior Investigator Award, two Wellcome Collaborative Awards and a number of joint awards with colleagues in the MRC-CMM and LSI.
Relationships with staff in the LSI:
- I am a co-applicant on a project called the Molecular Mechanic Initiative (MMI) supported by EPSRC Physics for Life grant led by Professor Frank Vollmer and team of co-investigators. This is using nanoparticle technologies and single molecule sensors to investigate fungal cell wall binding proteins.
- I am a co-applicant on BBSRC equipment grant award led by Professor Gaspar Jekely that funds cryo-fixation/ freeze-substitution equipment underpinning high resolution electron microscopy and tomography.
- I am working with Dr Caitlin Chimerel investigating the pharmacodynamics of AmBisome (and antifungal drug that is delivered in a liposomal formulation), using cavity enhanced absorption spectroscopy that has th potential to make single cell measurements of drug translocation.
- I am beginning to investigate how novel microfluidic methodologies can be applied to study fungus-drug interactions with a new team of LSI researchers.
Toh Kian Chui Distinguished Professor and Professor of Developmental Biology
Principal Investigator, Developmental Genetics Laboratory
Chief Scientist, Skin Research Institute of Singapore, Agency for Science, Technology & Research (A*STAR)
Chief Scientist, Chairman, Chugai Pharmabody Research Pte Ltd, Agency for Science, Technology and Research (A*STAR)
Lee Kong Chian School of Medicine, Singapore Nanyang Technological University, Singapore Director of Nanyang Institute of Structural Biology, Singapore