Dr Brandon Invergo
My research is generally in the area of evolutionary systems biology, wherein I am interested in the structure, dynamics and evolution of intracellular-protein signaling networks. In particular, I focus on how natural selection acts on pathway-level signaling dynamics. For example, how evolvable are non-linear dynamic traits that are determined by the interactions of multiple proteins? How significantly do signaling dynamics vary between individuals, populations, or species? Where has natural selection produced unusually fast/slow dynamics? At what point do altered dynamics become dysregulation and disease? Together, this requires: a) measuring signaling processes, b) reconstructing signaling pathways and analyzing them through mathematical models, c) modeling molecular evolutionary histories, and d) performing comparative analyses of protein signaling.