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Dr Brandon Invergo

Dr Brandon Invergo

Research Fellow

 

Overview

My research is generally in the area of evolutionary systems biology, wherein I am interested in the structure, dynamics and evolution of intracellular-protein signaling networks.  In particular, I focus on how natural selection acts on pathway-level signaling dynamics. For example, how evolvable are non-linear dynamic traits that are determined by the interactions of multiple proteins? How significantly do signaling dynamics vary between individuals, populations, or species? Where has natural selection produced unusually fast/slow dynamics? At what point do altered dynamics become dysregulation and disease?  Together, this requires: a) measuring signaling processes, b) reconstructing signaling pathways and analyzing them through mathematical models, c) modeling molecular evolutionary histories, and d) performing comparative analyses of protein signaling.

View my profile on the Mathematics website.

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