Stem Cell Models of Neurodegenerative Disorders
Stem Cell Models
We aim to understand why neurons die in age-onset neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Frontotemporal Degeneration and Alzheimer’s disease. We generate clinically relevant human models of neurodegenerationin vitroby differentiating patient-derived or genome edited stem cells into clinically relevant neurons and glia. Using a combination of bulk and single-cell genomics, bioinformatics, and high-throughput functional screens, we interrogate these models to elucidate the regulatory networks that drive neuronal death. Our ultimate goal is to identify key disease drivers that can be used to develop therapies to halt or even reverse the relentless neuronal loss.
We recieve funding from Medical Research Council, Academy of Medical Sciences, and Royal Society Motor Neuron Disease Association.
Stem Cell Models - who we are
|Dr Akshay Bhinge||LSI Research Fellow|
|Dr Seema Namboori||Graduate Research Assistant|
|Sophie Hawkins||PhD Student|
|James Moran||PhD Student|
|Johanna Ganssauge||PhD Student|
|Jessica Board||MbyRes Student|