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Stem Cell Models of Neurodegenerative Disorders 

Stem Cell Models

We aim to understand why neurons die in age-onset neurodegenerative diseases such as Amyotrophic Lateral Sclerosis, Frontotemporal Degeneration and Alzheimer’s disease. We generate clinically relevant human models of neurodegenerationin vitroby differentiating patient-derived or genome edited stem cells into clinically relevant neurons and glia. Using a combination of bulk and single-cell genomics, bioinformatics, and high-throughput functional screens, we interrogate these models to elucidate the regulatory networks that drive neuronal death. Our ultimate goal is to identify key disease drivers that can be used to develop therapies to halt or even reverse the relentless neuronal loss. 

We recieve funding from Medical Research Council, Academy of Medical Sciences, and Royal Society Motor Neuron Disease Association.


Stem Cell Models - who we are

 Dr Akshay Bhinge  LSI Research Fellow
 Dr Seema Namboori   Graduate Research Assistant
 Sophie Hawkins  PhD Student
 James Moran  PhD Student
 Johanna Ganssauge  PhD Student
 Jessica Board  MbyRes Student