Video

Professor Andrew Randall researches into circuits in the brain and how brain cells talk to each other, and how these go wrong in neurological diseases which cause dementia.

850,000 people are living with dementia in the UK today

Brain networks and dementia

To aid early diagnosis and the quest for better treatments, our research seeks to find out more about how the brain’s circuits malfunction in dementia.

These neuronal circuits influence how we experience the world, and damage to these connections cause many of the distressing symptoms associated with dementia, from a lack of spatial orientation and awareness to memory loss and psychosis.

In order to explore what causes this, we make electrical measurements of cell activity and circuit function in the brain to probe how such problems lead to the symptoms of dementia including Alzheimer’s disease. The team use both mouse models and human neurones produced from stem cells to gain a much deeper insight into what goes wrong in the brain in dementia, with a view to identifying targets for new treatments and therapies. 

Brain networks and dementia - primary investigators

NameRoleKeywords
Professor Andrew Randall         Professor in Applied Neurophysiology Neurophysiology, electrophysiology, cellular imaging, Alzheimer’s Disease 
Dr Jonathan Brown   Senior Lecturer Neurophysiology, Alzheimer’s disease, frontotemporal dementia, schizophrenia, Synaptic and intrinsic neurophysiology. 
Dr Mick Craig   Research Fellow Neural circuit mapping, inhibitory interneurons, neuronal oscillations, optogenetics, chemogenetics, electrophysiology, behaviour, Alzheimer’s disease and psychiatric illness