Understanding and curing human diseases

Research using mouse models to understand the basis of human disease and translating these discoveries into new therapies.

Professor Gordon Brown utilizes mice to model and understand the basis of human diseases. His research has led to the discovery of genetic alterations (polymorphisms) in human genes that underlie susceptibility to infectious diseases, including fungal infections and tuberculosis. This research has also directly led to a cure of a devastating fungal skin infection, called chromoblastomycosis. 

His work has uncovered immune mechanisms that exacerbate the severity of autoimmune and inflammatory diseases, such as rheumatoid arthritis, lupus and severe COVID 19.  These discoveries suggest novel avenues for the development of new therapies that can help treat these, and other, diseases.