Dr Katie Lunnon talks about her research, which explores the genomic factors in dementia.
Genomics of dementia
Our Complex Disease (Epi)genomics Group uses cutting-edge methods to explore the causes and consequences of molecular variation in the brain, and the role this may play in aging and the onset of diseases including dementia.
We study the epigenetic processes that regulate gene expression, and explore how changes in gene function impact human health. There is growing interest in the role of epigenetic variation in mediating the interplay between genes and the environment. Disease-associated epigenetic marks are potentially reversible, therefore representing possible targets for the development of new drugs.
We use novel genomic profiling methods and sophisticated bioinformatics analyses to explore regulatory genomic variation in post-mortem brain samples, population-based cohorts and established models (animal and cellular) of dementia.
Genomics of dementia - primary investigators
| Name | Role | Keywords |
|---|---|---|
| Professor Jonathan Mill | Professor of Epigenetics | Genomics, epigenetics, gene function, animal models, brain, transcription, bioinformatics |
| Dr Katie Lunnon | Associate Professor in Epigenetics | Genomics, epigenetics, gene function, animal models, brain, transcription, bioinformatics |
| Dr Byron Creese | Senior Research Fellow | Genomics, genome-wide data analysis, neuropsychiatric symptoms in dementia |
| Dr Eilis Hannon | Research Fellow | Genomics, psychiatric disorders, bioinformatics |
| Dr Rebecca Smith | Research Fellow | Epigenetics, Alzheimer’s Disease |
| Dr Ehsan Pishva | Research Fellow | Epigenetics, stress, depression, Alzheimer’s Disease |