Complex Trait Genomics
The Complex Trait Genomics of Diabetes group is a multidisciplinary team of scientists at the University of Exeter Medical School.
Its research has two broad aims:
- First, to identify the variants in the human genome responsible for common diseases and traits, with a focus on cardiometabolic diseases. These include type 2 diabetes, and its key features, insulin secretion and resistance; obesity; growth (including fetal growth), female reproductive lifespan (including age at menopause) and cancers which are associated with type 2 diabetes and obesity.
- Second, to use human genetics to help understand the biology of these diseases.
Approaches include Mendelian randomization, functional genomics and bioinformatics, stratified heritability analysis, fine-mapping, recall-by-genotype studies with the help of the Exeter 10,000 research volunteers and the NIHR National BioResource, and the use of genetic scores to help dissect disease heterogeneity.
Name | Role |
---|---|
Professor InĂªs Barroso | Professor of Diabetes |
Professor Tim Frayling | Professor of Human Genetics |
Associate Professor Mike Weedon | Associate Professor of Bioinformatics |
Professor Anna Murray | Professor in Human Genetics |
Professor Caroline Wright | Professor in Genomic Medicine |
Associate Professor Mattia Frontini | Associate Professor of Cell Biology and BHF Research Fellow |
Professor Chrissie Thirwell | Mireille Gillings Professor of Cancer Genomics |
Dr Andrew Wood | Senrior Lecturer in Computational and Statistical Genetics |
Dr Rachel Freathy | Associate Professor and Wellcome Trust Senior Research Fellow |
Dr Nick Owens | Lecturer in Data Science and AI |
Dr Hanieh Yaghootkar | Diabetes UK RD Lawrence Research Fellow |
Dr Jess Tyrell | Senior Lecturer |
Dr Ji Chen | Research Fellow |
Dr Gareth Hawkes | Research Fellow |
Dr Robin Beaumont | Research Fellow |
Dr Francesco Casanova | Research Fellow |
Dr Susan Martin | Postdoctoral Research Associate |
Dr Kate Ruth | Research Fellow |
Brandon Lim | Graduate Research Assistant |
Please find a selection of the group's key and landmark papers below. Full publications lists are available on individual biographies:
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa
The molecular logic of Nanog-induced self-renewal in mouse embryonic stem cells