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Publications

_{Copyright Notice: Any articles made available for download are for personal use only. Any other use requires prior permission of the author and the copyright holder.}

| 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2007 |

2024

• Bottomley H, Phillips J, Hart P. (2024) Improved Detection of Tryptic Peptides from Tissue Sections Using Desorption Electrospray Ionization Mass Spectrometry Imaging, Journal of the American Society for Mass Spectrometry, DOI:10.1021/jasms.4c00006. [PDF]

2023

• Kish M, Ivory DP, Phillips JJ. (2023) Transient Structural Dynamics of Glycogen Phosphorylase from Nonequilibrium Hydrogen/Deuterium-Exchange Mass Spectrometry, Journal of the American Chemical Society, volume 146, no. 1, pages 298-307, DOI:10.1021/jacs.3c08934. [PDF]
• Kish M, Ivory DP, Phillips JJ. (2023) Allosteric activation and inhibition of glycogen phosphorylase share common transient structural features, DOI:10.1101/2023.06.03.543583. [PDF]
• Kish M, Subramanian S, Smith V, Lethbridge N, Cole L, Vollmer F, Bond NJ, Phillips JJ. (2023) Allosteric Regulation of Glycogen Phosphorylase by Order/Disorder Transition of the 250′ and 280s Loops, Biochemistry, volume 62, no. 8, pages 1360-1368, DOI:10.1021/acs.biochem.2c00671. [PDF]
• Kish M, Smith V, Lethbridge N, Cole L, Bond NJ, Phillips JJ. (2023) Online Fully Automated System for Hydrogen/Deuterium-Exchange Mass Spectrometry with Millisecond Time Resolution, Analytical Chemistry, volume 95, no. 11, pages 5000-5008, DOI:10.1021/acs.analchem.2c05310. [PDF]
• Seetaloo N. (2023) Synuclein plasticity: the Achilles’ heel of nerve function linked to the onset of Parkinson’s disease.

2022

• Seetaloo N, Zacharopoulou M, Stephens AD, Kaminski Schierle GS, Phillips JJ. (2022) Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry Approach to Correlate Local Structure and Aggregation in α-Synuclein, Analytical Chemistry, volume 94, no. 48, pages 16711-16719, DOI:10.1021/acs.analchem.2c03183. [PDF]
• Seetaloo N, Phillips JJ. (2022) Millisecond Hydrogen/Deuterium-Exchange Mass Spectrometry for the Study of Alpha-Synuclein Structural Dynamics under Physiological Conditions, Journal of Visualized Experiments, volume 2022, no. 184, DOI:10.3791/64050.
• Orozco CT, Bersellini M, Irving LM, Howard WW, Hargreaves D, Devine PWA, Siouve E, Browne GJ, Bond NJ, Phillips JJ. (2022) Mechanistic insights into the rational design of masked antibodies, mAbs, volume 14, no. 1, DOI:10.1080/19420862.2022.2095701. [PDF]
• Guo Z, Parakra RD, Xiong Y, Johnston WA, Walden P, Edwardraja S, Moradi SV, Ungerer JPJ, Ai HW, Phillips JJ. (2022) Engineering and exploiting synthetic allostery of NanoLuc luciferase, Nature Communications, volume 13, no. 1, DOI:10.1038/s41467-022-28425-2.
• Seetaloo N, Zacharopoulou M, Stephens AD, Kaminski Schierle GS, Phillips JJ. (2022) Local structural dynamics of alpha-synuclein correlate with aggregation in different physiological conditions, DOI:10.1101/2022.02.11.480045. [PDF]

2021

• Seetaloo N, Kish M, Phillips JJ. (2021) HDfleX: Software for flexible high structural resolution of hydrogen/deuterium-exchange mass spectrometry data, DOI:10.1101/2021.12.09.471740. [PDF]
• Orozco CT, Edgeworth MJ, Devine PWA, Hines AR, Cornwell O, Thompson C, Wang X, Phillips JJ, Ravn P, Jackson SE. (2021) Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation, Bioconjugate Chemistry, volume 32, no. 8, pages 1834-1844, DOI:10.1021/acs.bioconjchem.1c00286. [PDF]
• Groves K, Ashcroft AE, Cryar A, Sula A, Wallace BA, Stocks BB, Burns C, Cooper-Shepherd D, De Lorenzi E, Rodriguez E. (2021) Reference Protocol to Assess Analytical Performance of Higher Order Structural Analysis Measurements: Results from an Interlaboratory Comparison, Anal Chem, volume 93, no. 26, pages 9041-9048, DOI:10.1021/acs.analchem.0c04625. [PDF]

2020

• Stephens AD, Zacharopoulou M, Moons R, Fusco G, Seetaloo N, Chiki A, Woodhams PJ, Mela I, Lashuel HA, Phillips JJ. (2020) Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity, Nature Communications, volume 11, no. 1, DOI:10.1038/s41467-020-16564-3.

2019

• Stephens AD, Zacharopoulou M, Moons R, Fusco G, Seetaloo N, Chiki A, Hooper PJ, Mela I, Lashuel HA, Phillips JJ. (2019) Extent of N-terminus exposure by altered long-range interactions of monomeric alpha-synuclein determines its aggregation propensity, DOI:10.1101/740241. [PDF]
• Kish M, Smith V, Subramanian S, Vollmer F, Lethbridge N, Cole L, Bond NJ, Phillips JJ. (2019) Allosteric regulation of glycogen phosphorylase solution phase structural dynamics at high spatial resolution, DOI:10.1101/654665. [PDF]
• Zacharopoulou M, Stephens A, Mela I, Moons R, Sobott F, Phillips J, Schierle GK. (2019) Disruption of monomeric alpha-synuclein long-range interactions alters its misfolding propensity, EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, volume 48, pages S88-S88. [PDF]

2018

• Stephens AD, Nespovitaya N, Zacharopoulou M, Kaminski CF, Phillips JJ, Kaminski Schierle GS. (2018) Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing, Anal Chem, volume 90, no. 11, pages 6975-6983, DOI:10.1021/acs.analchem.8b01264. [PDF]
• Lautenschläger J, Stephens AD, Fusco G, Ströhl F, Curry N, Zacharopoulou M, Michel CH, Laine R, Nespovitaya N, Fantham M. (2018) C-terminal calcium binding of α-synuclein modulates synaptic vesicle interaction, Nat Commun, volume 9, no. 1, DOI:10.1038/s41467-018-03111-4. [PDF]

2017

• Phillips JJ, Buchanan A, Andrews J, Chodorge M, Sridharan S, Mitchell L, Burmeister N, Kippen AD, Vaughan TJ, Higazi DR. (2017) Rate of Asparagine Deamidation in a Monoclonal Antibody Correlating with Hydrogen Exchange Rate at Adjacent Downstream Residues, Analytical Chemistry, volume 89, no. 4, pages 2361-2368, DOI:10.1021/acs.analchem.6b04158. [PDF]

2016

• Millership C, Phillips JJ, Main ERG. (2016) Ising Model Reprogramming of a Repeat Protein's Equilibrium Unfolding Pathway, Journal of Molecular Biology, volume 428, no. 9, pages 1804-1817, DOI:10.1016/j.jmb.2016.02.022.
• Borisov OV. (2016) State-of-the-art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization Defining the next generation of analytical and biophysical techniques, ACS Symposium.
• Dobson CL, Devine PWA, Phillips JJ, Higazi DR, Lloyd C, Popovic B, Arnold J, Buchanan A, Lewis A, Goodman J. (2016) Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo, Scientific Reports, volume 6, no. 1, article no. 38644, DOI:10.1038/srep38644. [PDF]

2015

• Remmele RL, Bee JS, Phillips JJ, Mo WD, Higazi DR, Zhang J, Lindo V, Kippen AD. (2015) Characterization of Monoclonal Antibody Aggregates and Emerging Technologies, ACS Symposium Series, volume 1202, pages 113-158, DOI:10.1021/bk-2015-1202.ch005.
• Klein T, Vajpai N, Phillips JJ, Davies G, Holdgate GA, Phillips C, Tucker JA, Norman RA, Scott AD, Higazi DR. (2015) Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase, Nature Communications, volume 6, no. 1, article no. 7877, DOI:10.1038/ncomms8877. [PDF]
• Edgeworth MJ, Phillips JJ, Lowe DC, Kippen AD, Higazi DR, Scrivens JH. (2015) Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability, Angew Chem Int Ed Engl, volume 54, no. 50, pages 15156-15159, DOI:10.1002/anie.201507223. [PDF]

2014

• Tavakoli-Keshe R, Phillips JJ, Turner R, Bracewell DG. (2014) Understanding the relationship between biotherapeutic protein stability and solid-liquid interfacial shear in constant region mutants of IgG1 and IgG4, J Pharm Sci, volume 103, no. 2, pages 437-444, DOI:10.1002/jps.23822. [PDF]

2013

• Main ERG, Phillips JJ, Millership C. (2013) Repeat protein engineering: creating functional nanostructures/biomaterials from modular building blocks, Biochem Soc Trans, volume 41, no. 5, pages 1152-1158, DOI:10.1042/BST20130102. [PDF]

2012

• Phillips JJ, Javadi Y, Millership C, Main ERG. (2012) Modulation of the multistate folding of designed TPR proteins through intrinsic and extrinsic factors, Protein Sci, volume 21, no. 3, pages 327-338, DOI:10.1002/pro.2018. [PDF]
• Phillips JJ, Millership C, Main ERG. (2012) Fibrous nanostructures from the self-assembly of designed repeat protein modules, Angew Chem Int Ed Engl, volume 51, no. 52, pages 13132-13135, DOI:10.1002/anie.201203795. [PDF]

2007

• Phillips JJ, Yao Z-P, Zhang W, McLaughlin S, Laue ED, Robinson CV, Jackson SE. (2007) Conformational dynamics of the molecular chaperone Hsp90 in complexes with a co-chaperone and anticancer drugs, J Mol Biol, volume 372, no. 5, pages 1189-1203, DOI:10.1016/j.jmb.2007.04.059. [PDF]

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