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Researchers

Arran Hodgkinson

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: A.B.J.Hodgkinson@exeter.ac.uk

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Brandon Invergo

I am interested in the structure, dynamics and evolution of intracellular protein signaling networks.  In particular, I focus on how natural selection on pathway-level signaling dynamics is translated into evolution of the underlying proteins.  Initially I worked on this topic during my PhD research in Barcelona (Pompeu Fabra University) via mathematical models and bioinformatics for the visual phototransduction system.  As an ESPOD fellow at the European Bioinformatics Institute and the Wellcome Trust Sanger Institute, I further broadened my approach to include quantitative mass spectrometry and integrative 'omics analyses.  I applied these methods to investigate rapid phosphorylation- based signaling in malarial parasites and to predict novel signaling relationships between human protein kinases.

As a TREE fellow, I will continue in this direction with the aim of gaining a clearer understanding of sequence-level determinants of variation in complex signaling dynamics in the contexts of evolution and disease.

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: b.invergo@exeter.ac.uk

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Piotr Slowinski

Please click here to see Piotr's profile on the University of Exeter web pages.