Evolution and Mechanisms
The United Nations has recognised that tackling the spread of antimicrobial resistance (AMR) in the environment as one of the greatest emerging environmental concerns in the world.
At Exeter we explore the evolution of antimicrobial resistance to understand and potentially hinder this process. We aim to establish a blueprint for how to best manage AMR in clinical and environmental settings. Currently, resistant bacteria are released into the natural environment through contamination of streams, rivers, seawater soil. The environment is impacted by antimicrobials and AMR organisms through animal waste on farms or through human sewage treatment plant effluent. Exeter’s research focuses on new ways to break this damaging cycle.
We also study the evolution of resistance in clinical pathogens and in in complex microbial communities found in human and animal microbiomes. Many fungal pathogens are also ubiquitous in the environment and are developing resistance to frontline clinical antifungal drugs via selection in the environment, especially from antifungals routinely sprayed on a variety of crops.
The molecular and evolutionary pathways explaining the emerging antifungal resistance need to be explored. We aim to obtain an increased insight in those mechanisms to find targets to intervene.
Evolution - primary investigators
|Professor William Gaze||Professor of Microbiology||Environment, policy, microbiome, evolution ecology, public health, agriculture, evidence|
|Professor Robert Beardmore||Professor of Mathematical Biosciences||Mathematical modelling, evolutionary datasets, antibiotic resistance|
|Dr Lihong Zhang||Research Fellow||Antibiotics resistance, molecular microbiology, environmental microbiology, medical microbiology, microbial ecology|
|Professor Angus Buckling||Professor of Evolutionary Biology||Evolutionary ecology, antimicrobial resistance|
|Dr Michiel Vos||Senior Lecturer||Microbiology, evolutionary ecology, population genomics, bacterial genome evolution, ecology of antibiotic resistance and virulence genes|
|Professor Neil Gow||Professor of Microbiology and Deputy Vice-Chancellor (Research and Impact)||Antifungal resistance, Candida auris, antifungal drug transit, drug resistance mechanisms, echinocandins, antifungal drugs, antifungal therapies|
|Professor Adilla Warris||Professor in Paediatric Infectious Diseases and Deputy Director MRC Centre for Medical Mycology||Antifungal resistance, azole-resistant Aspergillus fumigatus, evolution, clinical implications|
|Professor Al Brown||Deputy Director MRC Centre for Medical Mycology||Antifungal resistance, evolution|
|Professor Edze Westra||Professor / NERC Independent Research Fellow||Ecological variables, evolution, immune strategies, bacteria, Phage, CRISPR|
|Dr Stineke Van Houte||BBSRC Future Leadership Fellow||CRISPR-Cas, bacteria-phage interactions, AMR plasmid spread in microbial communities|
|Dr Uli Klümper||Marie Curie Fellow||AMR selection dynamics, Plasmids, Horizontal gene transfer|
|Professor Stuart Townley||Professor in Applied Mathematics||Systems modelling, analysis and management|
|Dr Aimee Murray||NERC Fellow||Culturing, molecular methods (qPCR, cloning, functional metagenomics), next generation sequencing, metagenome analyses, evolution experiments|
|Dr Ben Raymond||Associate Professor||Experimental evolutionary ecology, insects, plants, bacterial pathogens and symbionts, virulence and resistance, parasites, symbionts, Bacillus thruringiensis and resistance to antibiotics.|
|Dr Rhys Farrer||Lecturer in Bioinformatics at MRC Centre for Medical Mycology||Genome sequencing, hospital outbreak strains, C. auris, C. neoformans, C. gattii, environmental sequencing, variant discovery in antifungal targets, ERG11, tool/database development of drug resistance alleles, MARDy|
|Dr Alan Brown||Senior Lecturer in Molecular Microbiology||Molecular bacteriology; niche adaptation and antimicrobial resistance; host-pathogen interactions; immunotherapy.|
|Professor Ivana Gudelj||
Professor of Evolutionary Systems Biology
|Mathematical modelling, multi-species communities, evolution, antifungals|
|Senior Lecturer in Biochemistry||Bacterial signal transduction, novel antimicrobial development, kinase inhibitors, sensor kinase, protein biochemistry, Pseudomonas aeruginosa and Burkholderia pseudomallei.|
|Chair in Food Security||Antifungals, fungicide resistance, evolution, global movement and stewardship of antifungals|
|Clinical Lecturer in Respiratory Medicine||Bronchiectasis; Cystic Fibrosis; lung disease; cross-infection; microbiome; antimicrobial resistance|