Technology and Data

Using technology is a key part of managing and reducing antimicrobial resistance (AMR). We utilise interdisciplinary research in mathematical modelling, the development of tools and databases, and data analysis to look at AMR through a new lens.

Our rigorous research techniques put us at the cutting edge of technological development, investigating fresh approaches to control AMR. Using synthetic biology, we take the principles of engineering and apply them to the biological system. At the forefront of our research is the search for alternatives to simple drugs that infectious agents have become resistant to, and technologies such as CRISPR to edit the genomes of bacteria, fungi and other microbes.

Technology and Data - primary investigators

Name	Role	Keywords
Professor Robert Beardmore	Professor of Mathematical Biosciences	Mathematical modelling; data analysis
Dr Mario Recker	Associate Professor in Applied Mathematics	Antigenically and phenotypically diverse pathogens, Plasmodium falciparum, dengue, Staphylococcus aureus, mathematical and data analytic frameworks, pathology, evolutionary epidemiology, host-pathogen interactions, gene expression, immune selection
Dr Stuart Daines	Research Fellow	Marine ecology, biochemistry, coevolution, physical environment
Professor Stuart Townley	Professor in Applied Mathematics	Systems modelling, analysis and management
Dr Remy Chait	Lecturer	Technology development, bioscience
Dr Tobias Bergmiller	Lecturer	Technology development, molecular biology
Dr Stefano Pagliara	Senior Lecturer in Microfluidics	Technology development, single-cell response, membrane transport, drug uptake, antibiotic tolerance, ageing
Dr Jehangir Cama	Industry Research Fellow	Single-cell phenotyping, drug development assays, membrane transport, technology development
Professor Ivana Gudelj	Professor of Evolutionary Systems Biology	Mathematical modelling, synthetic biology, multi-species communities
Dr Lihong Zhang	Research Fellow	Molecular microbiology, environmental microbiology, medical microbiology, microbial ecology
Dr Stineke Van Houte	BBSRC Future Leadership Fellow	CRISPR-Cas9 gene drives to fight AMR, phage identification, phage-based approaches to fight pathogenic infections
Professor Adilia Warris	Professor in Paediatric Infectious Diseases and Deputy Director MRC Centre for Medical Mycology	Azole-resistant A. fumigatus, CRISPR
Professor Henry Buller	Professor of Geography, Head of Exeter Geography	Social science approaches to diagnostic pathways and diagnostic tool development in clinical veterinary science
Dr Rhys Farrer	Lecturer in Bioinformatics at MRC Centre for Medical Mycology	Tool/database development, genomic and transcriptomic changes, micro evolutionary and species comparisons, ChIPseq, chromatin regulation, gene expression
Dr Alan Brown	Senior Lecturer in Molecular Microbiology	Molecular bacteriology, niche adaptation and antimicrobial resistance, host-pathogen interactions immunotherapy
Dr Steven Porter	Senior Lecturer in Biochemistry	Bacterial signal transduction, novel antimicrobial development, kinase inhibitors, sensor kinase, protein biochemistry, Pseudomonas aeruginosa, Burkholderia pseudomallei.
Dr Mike Allen	Associate Professor of Single Cell Genomics	Antibiotic resistance, molecular microbiology, environmental microbiology, medical microbiology, microbial ecology, feed/energy conversion, oceans and human health; environment and human health, technology development
Professor Sarah Gurr	Chair in Food Security	Antifungals, fungicide resistance, evolution, global movement and stewardship of antifungals
Professor Andrew Shaw	Associate Professor of Physical Chemistry	Attomarker, physical chemistry, screening, biomarkers, disease, differential diagnostics