Trial Portfolio

Ongoing studies

TrialDescriptionChief Investigator(s)


Examining  the clinical effectiveness and the cost-effectiveness of electronic decision support embedded within primary care IT systems in the early diagnosis of symptomatic cancer 

Prof. Willie Hamilton 


Study of dementia identification system (DECODE), and its use in primary care and as a memory clinic triage tool. Dr David Llewellyn


Assessing and Enhancing Emotional Competence for Well-being in the Young: A principled, evidence based, mobile health approach to prevent mental disorders and promote mental well-being in the young Professor Ed Watkins


Development and feasibility testing of an intervention: To facilitate the involvement of older patients with multimorbidity in decision making about their healthcare during general practice consultations. Dr Joanne Butterworth


Multicentre, Double Blind, Randomised Controlled Trial of 10kHz High- Frequency Spinal Cord Stimulation for Chronic Neuropathic Low Back Pain Dr Adnan Al-Kaisy


Improving the experience of dementia and enhancing active life: a longitudinal perspective on living well with dementia Professor Linda Clare 




Examining the use of insulin degludec for frail elderly patients with diabetes in institutional care Dr David Strain
Microbio The oral microbiome and NO bioavailability across the human lifespan. Can the oral microbiome be manipulated through dietary intervention and what are the consequences for no bioavailability and indices of cardiovascular health in young and older adults? Professor Andrew Jones/ Dr Anni Vanhatalo
THRIVE The clinical and cost effectiveness of adapted Dialectical Behaviour Therapy (DBT) for Bipolar Mood Instability in primary care Dr Kim Wright


Singing groups to help improve wellbeing for those with post-stroke aphasia Dr Mark Tarrant


Sensitivity and Specificity of a mobile lead-one ECG like device for the detection of
Atrial Fibrillation (AF)
Phil Keeling/Dr Chris Clark


Does a screening trial for spinal cord stimulation in patients with chronic pain of neuropathic origin have clinical utility and cost-effectiveness? Sam Eldabe


 The association between inter-arm blood pressure difference, cardiovascular disease, and mortality: an Individual Patient Data meta-analysis (INTERPRESS-IPD Dr Chris Clark 
REACH-HF Rehabilitation Enablement in Chronic Heart Failure Prof. Rod Taylor and  Dr Hayes Dalal 
HeLP The Healthy Lifestyles Programme Trial
ISRCTN description
Assoc. Prof Katrina Wyatt
STARS Supporting Teachers and Children in Schools
ISRCTN description
Prof. Tamsin Ford
PANTS Personalising Anti-TNF therapy in Crohn disease Dr Tariq Ahmad
ExTraMATCH II Exercise training for chronic heart failure Prof Rod Taylor
IMPROVE-2 Implementing multifactorial psychotherapy research in online virtual environments
ISRCTN description
Prof. Ed Watkins
TriMaster Study of a DPP4 Inhibitor, SGLT2 Inhibitor and Thiazolidinedione as Third Line Thera-py in Patients With Type 2 Diabetes. Prof. Andrew Hattersley
ReTrain Community-based Rehabilitation Training after Stroke  Dr Sarah Dean
IDEAL-2 Improving the experience of Dementia and Enhancing Active Life Professor Linda Clare

 Completed studies

TrialDescriptionChief investigator(s)
Esteem Study of the effectiveness and cost effectiveness of telephone triage of patients requesting same day consultations in general practice: a cluster randomised controlled trial comparing nurse-led and GP-led management systems with usual care. Prof. John Campbell
COBRA Cost and Outcome of BehaviouRal Activation Prof. Dave Richards
CADENCE CAre in carDiac rEhabilitatioN serviCEs for patients with new onset depression  Prof. John Campbell
BAcPAc Integrating Behavioural Activation and Physical Activity promotion  Prof Paul Farrand
PREVENT Effectiveness and cost-effectiveness of mindfulness-based cognitive therapy compared with maintenance antidepressant treatment in the prevention of depressive
relapse or recurrence
Prof William Kuyken (formerly Department of Psychology, Exeter)