Development, Stem cells & Disease
This area concerns how cells specialise and organise themselves to form complex tissues and organs. We use Drosophila, zebrafish, highly regenerative invertebrates, and ex vivo animal and human stem cells to study the biochemical signals, biophysical cues and gene regulatory networks that govern cell fate decisions and morphogenesis. We combine these experimental systems with mathematical and computational modelling to understand how signalling and cell fate go awry in conditions such as pregnancy failure, cancer, diabetes and neurological disorders, and to identify new approaches to therapy.
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