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Current research

Current Research

Current Research

Current Research

This page outlines the current research projects running in our three research pathways:

  1. Hard to treat depression
  2. Bipolar
  3. Recovery and resilience

For more information on how to get involved in any of the research, please see details within each section.

Stream 1: Hard-to-treat depression

There are a number of individuals who do not respond to current best practice psychological therapies and we have a number of research projects investigating the effectiveness of different psychological therapies for hard-to-treat depression.

This case series project adapts a psychological therapy called ‘ADepT’, which aims to build wellbeing and alleviate depression symptoms, to focus on individuals with complex depression.

The AccEPT clinic is working in collaboration with ‘Inclusion Thurrock’ in Essex to recruit a total of 30 individuals experiencing complex depression to take part in a multiple randomised baseline case series.

The AccEPT clinic is hosting this project and all treatment is being delivered by AccEPT therapists. This project was funded by a through a Saudi Arabian government PhD award to Batool AlsayadNasser and National Institute of Health Research (NIHR) funding awarded to Richard Pione.

If you have questions about the case series, please contact Batool Alalsayednasser at

Please note, this project has now successfuly finished recruitment and is now closed.

The ADepT-YP project aims to adapt the ‘ADepT’ wellbeing protocol already used in previous work to focus specifically on the treatment of young adults experiencing an episode of depression. A two-wave, multiple randomised baseline case series has finished a first wave, recruiting 11 students from the University wellbeing service who were experiencing depression and is now beginning its second wave, aiming to recruit 15 young adults with depression from therapy waiting lists at ‘Talkworks’ Talking Therapies for depression and anxiety in Devon. The first wave showed promising evidence of acceptability and feasibility, the second wave will add to this by gathering evidence to assess its clinical efficacy.

For more information please contact James Carson at

This case series project looks to see whether a psychological therapy called ‘ADepT ’ can be useful for individuals with depression who have previously not responded to a current best practice therapy (e.g., cognitive behavioural therapy) in NHS Talking Therapies for depression and anxiety services (formerly known as ‘Improving Access to Psychological Therapy’ or IAPT). This case series will recruit a total of 12 participants who have previously not responded to depression treatment and the study will commence in December 2023.

For more information please contact 

Stream 2: Bipolar

We have a number of research projects focusing on psychological therapies for individuals with Bipolar disorder.

This study looks at a talking therapy programme for people with bipolar or cyclothymic disorder who are currently experiencing ongoing low mood or mood swings outside of major episodes of depression or mania.

More information about STABILISE and how to take part can be found here.

The treatment offers up to 12 sessions of cognitive behavioural therapy adapted to focus on supporting individuals with bipolar disorder who experience difficulties with impulsive behaviours. The AccEPT clinic is working collaboratively with colleagues in Southampton to recruit a maximum of 10 participants from Devon or Southampton.

This study is open to recruitment, so if you are interested in finding out more please email Jan Freeman on

Stream 3: Resilience and Recovery

This stream of research focuses on interventions to build resilience and aid recovery for individuals with severe and enduring mental illness.

You can find out about other research being conducted within the Mood Disorders Centre and past research at the AccEPT Clinic, by visiting the links below

For further research that is performed outside of the Accept Clinic please see our Mood Disorders Centre pages

Learn more about our past research projects here