Nonlinear optics allows us to change the colour of light, manipulate its shape in space and time, and to create the shortest events ever made by humans. This module explores how light interacts with matter to create images, and the exciting nonlinear interactions that take place when light is squeezed into very short pulses.
You’ll get to see inside laser research laboratories for demonstrations of nonlinear optical imaging.
You’ll also learn the Physics that explains why gin & tonic fluoresces under UV light, and how to make cocktails that glow in the dark.
Pre-requisite modules: PHY1023, PHY1026, PHY2021 or equivalent modules.
Nonlinear optical imaging has emerged as a powerful tool offering significant advantages over conventional optical methods. This module aims to give students an introduction into the fundamental Physics underpinning these techniques, an overview of the instrumentation used, and their application in modern research applications.
INTENDED LEARNING OUTCOMES (ILOs) (see assessment section below for how ILOs will be assessed)
A student who has passed this module should be able to:
Module Specific Skills and Knowledge:
1. discuss the role of imaging and spectroscopy in the context of materials and life-sciences research;
2. explain how light-matter interactions can be exploited to obtain both structural and functional information of a sample;
3. discuss the shortcomings of conventional (linear) optical imaging methods and how nonlinear excitation can overcome some of these limitations;
4. demonstrate an understanding of the NLO processes that can be used to generate image contrast;
5. apply core Physics knowledge to explain, and solve quantitative problems related to both linear and nonlinear light-matter interactions;
6. demonstrate an understanding of the instrumentation used for nonlinear optical imaging and apply core Physics knowledge to solve quantitative problems related to the excitation and detection of NLO schemes;
7. demonstrate an understanding of the hazards associated high-powered lasers and be able perform laser safety calculations.
Discipline Specific Skills and Knowledge:
8. interpret information from literature;
9. demonstrate an understanding of how fundamental Physics can be applied to solve problems in different disciplines.
Personal and Key Transferable / Employment Skills and Knowledge:
10. ability to work in a multidisciplinary subject; in particular, the application of non-linear optics in a materials and life-sciences context;
11. perform laser safety calculations.
SYLLABUS PLAN - summary of the structure and academic content of the module
I. Introduction and Historical Perspective
II. Overview of Conventional (Linear) Optical Imaging
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Microscopy and spectroscopy in materials and life-sciences
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Optical contrast (phase, absorption, fluorescence)
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Vibrational spectroscopy (IR and Raman)
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Confocal detection
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Performance (depth penetration, photodamage, speed trade-off, photobleaching, staining, spatial resolution)
III. Fundamentals of Non-Linear Optical Processes
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Revision of light-matter interactions
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Non-linear optical interactions (non-linear susceptibility)
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Second-order processes
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Third-order processes
IV. Instrumentation for NLO imaging and spectroscopy
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Properties of ultrafast laser pulses and requirements for NLO
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Oscillators and amplifiers
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Frequency conversion
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Fibre-Sources
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Practical considerations for use of ultrafast lasers (pulse shapes, autocorrelations, dispersion, laser safety)
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Microscope and spectrometer design
V. Non-Linear Optical Imaging and Spectroscopy
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Multi-photon fluorescence
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Harmonic Generation (SHG and THG)
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Coherent anti-Stoke Raman Scattering (CARS and SRS)
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Other techniques â Sum Frequency Generation (SFG) and transient absorption
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Multi-modal imaging
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Performance (depth penetration, photodamage, speed trade-off, photobleaching, staining, spatial resolution)
VI. Applications and Future Perspectives
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Biological applications
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Clinical applications
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Materials and chemical applications