Structure-function studies of Coxiella burnetii O-antigen biosynthesis. PhD in Biosciences studentship (SWBio DTP) Ref: 3749
About the award
Prof Nicholas Harmer, Department of Biosciences, College of Life and Environmental Sciences, University of Exeter
Prof Clive Butler, Department of Biosciences, College of Life and Environmental Sciences, University of Exeter
Prof Joann Prior, Defence Science and Technology Laboratory
Location: University of Exeter, Streatham Campus, Exeter EX4 4QJ
The South West Biosciences Doctoral Training Partnership (SWBio DTP) is led by the University of Bristol, together with the Universities of Bath, Cardiff and Exeter, alongside Rothamsted Research. This partnership also includes the following collaborative partners; Marine Biological Association (MBA), Plymouth Marine Laboratory (PML), Swansea University, UCB Pharma, University of the West of England (UWE) and SETsquared Bristol.
These institutions represent a distinctive group of bioscience research staff and students, with established international, national and regional networks, and widely recognised research excellence. As research leaders, we have a strong track record in advancing knowledge through high-quality research and teaching, in partnership with industry and the government.
The programme particularly aims to provide students with outstanding interdisciplinary research training within the following themes:
- Advancing the frontiers of bioscience discovery
- Bioscience for sustainable agriculture and food
- Bioscience for an integrated understanding of health
Importantly this research training is also underpinned by transformative technologies, allowing you to expand the boundaries of your research through innovative tools, technologies and approaches.
For more information about the programme structure, please visit https://www.swbio.ac.uk/programme/.
Funding for 2020/21
These studentships are available to UK and EU nationals who have established UK residency (EU nationals must have ordinarily lived in the UK throughout the three years preceding the start of the studentship).
In this project, you will determine the mechanisms of two enzymes involved in Coxiella burnetii O-antigen biosynthesis. C. burnetii is an endemic pathogen of livestock, causing abortions, and is also a human pathogen. Its O-antigen is a strong vaccine candidate, and the biosynthesis requires novel enzymatic activities. The aim of the project will be to determine the structures of these enzymes using X-ray crystallography or cryo-electron microscopy as appropriate; and to relate the structure to function using a series of enzymatic approaches and molecular dynamics. This project will contribute to a wider programme aimed at using the O-antigen as a vaccine candidate against C. burnetii.
The project will offer the opportunity to learn a wide range of skills, including protein chemistry, molecular biology, structural biology, enzymology and molecular modelling. There will also be considerable opportunities to interact with the partner Dstl, and other collaborators in our wider network. The project will offer a challenging and interdisciplinary PhD in cutting edge research areas. All of these methods are well established in the supervisor’s group and their collaborators. There will be opportunities to also learn associated methods that the laboratories specialise in as the project develops. This project will be based in the recently established Living Systems Institute in Exeter, which houses a diverse group of leading interdisciplinary researchers. You will join a vibrant group of young researchers with interests across a range of diseases.
To be eligible for a fully-funded studentship, you must meet both the academic and residence criteria in line with UKRI guidelines. Please see the following webpage for further details https://www.swbio.ac.uk/programme/eligibility/.
A fully-funded four year SWBio DTP studentship will cover:
• a stipend* at the standard UKRI rate; currently £15,009 per annum for 2019-2020
• research and training costs
• tuition fees (at the standard UKRI rate)
• additional funds to support fieldwork, conferences and a 3-month internship
Applicants should have obtained, or be about to obtain, a First or Upper Second Class UK Honours degree, or the equivalent qualifications gained outside the UK, in an appropriate area of science or technology. Applicants with a Lower Second Class degree will be considered if they also have Masters degree or have significant relevant non-academic experience.
In addition, due to the strong mathematical component of the taught course in the first year and the quantitative emphasis in our projects, a minimum of a grade B in A-level Maths or an equivalent qualification or experience is required.
If English is not your first language you will need to have achieved at least 6.5 in IELTS and no less than 6.5 in any section by the start of the project. Alternative tests may be acceptable, please see http://www.exeter.ac.uk/postgraduate/apply/english/
Students from EU countries who do not meet the residency requirements may still be eligible for a fees-only award but no stipend. Applicants who are classed as International for tuition fee purposes are not eligible for funding.
For more informaton about entry requirements please visit https://swbio.ac.uk/programme/eligibility/.
Equality, Diversity and Inclusion Statement
We want to support diverse and inclusive work environments. We therefore welcome applications from individuals regardless of their race, ethnicity, sexual orientation, religion, age, gender, or disability status. We welcome applications from individuals who have previously studied at any recognised Higher Education Institute and from a range of career paths (please refer to the SWBio DTP academic criteria for eligibility), including individuals who have previously trained in the sciences and are wanting to return to scientific research.
We particularly encourage applications from BAME* and mature (this is classed as 30+ years) individuals as these backgrounds are currently underrepresented within our student cohort.
*Black, Asian and minority ethnic.
How to apply
Please be aware you will be asked to upload the following documents:
- Letter of application outlining your academic interests, prior research experience and reasons for wishing to undertake the project. Please indicate your preferred project choice if applying for multiple SWBio DTP projects.
Transcript(s) giving full details of subjects studied and grades/marks obtained. This should
be an interim transcript if you are still studying.
- Two academic references - see information below about references.
- If you are not a national of a majority English-speaking country you will need to submit evidence of your proficiency in English (see entry requirements above)
The closing date for applications is midnight on Monday, 2 December 2019. Interviews will be held at the University of Bristol in the weeks commencing 27 January 2020 and 3 February 2020.
You will be asked to name 2 academic referees as part of the application process. Your referees should not be from the prospective supervisory team.
If you are unable to obtain the reference documents to upload as part of the application process, please ensure that your academic referees email their references to firstname.lastname@example.org. Note that we will not be contacting referees to request references, you must arrange for them to be submitted to us by the deadline.
References should be submitted by your referees to us directly in the form of a letter. Referees must email their references to us from their institutional email accounts. We cannot accept references from personal/private email accounts, unless it is a scanned document on institutional headed paper and signed by the referee.
If you have any general enquiries about the application process please email email@example.com.
Project-specific queries should be directed to the primary supervisor.
Please note, the studentship selection process will take place in two stages:
1. The project supervisors will consider your application and may invite you to visit for an informal interview. You can apply for more than one SWBio DTP project, although supervisors may take into account your interest and commitment to their particular project. If you apply for multiple projects, please indicate your preferred project choice in your letter of application. Each application for an individual project will be considered separately by the project supervisors.
2. After closure of applications, each supervisory team will then nominate their preferred applicant. A shortlist will be selected from these nominations and shortlisted applicants will be invited for interview on a selection day at the University of Bristol. Please note that nomination by a project supervisor therefore does not guarantee the award of a studentship.
During the application process, the University may need to make certain disclosures of your personal data to third parties to be able to administer your application, carry out interviews and select candidates. These are not limited to, but may include disclosures to:
the selection panel and/or management board or equivalent of the relevant programme,
which is likely to include staff from one or more other HEIs;
- administrative staff at one or more other HEIs participating in the relevant programme.
Such disclosures will always be kept to the minimum amount of personal data required for the specific purpose. Your sensitive personal data (relating to disability and race/ethnicity) will not be disclosed without your explicit consent.
|Application deadline:||2nd December 2019|
|Value:||Tuition fees and an annual stipend allowance at Research Council rates, currently £15,009 per year for 2019-20|
|Duration of award:||per year|
|Contact: PGR Recruitment Officefirstname.lastname@example.org|