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Dr Aimee Murray

Dr Aimee Murray

NERC Innovation Fellow

 01326 259016

 Environment and Sustainability Institute 1.14

 

Environment and Sustainability Institute, University of Exeter, Penryn Campus, Penryn, Cornwall, TR10 9FE, UK

Overview

Dr Aimee Murray is a microbiologist researching the evolution and ecology of antimicrobial resistance, particularly in the environment. Using interdisciplinary approaches spanning microbiology, ecotoxicology and environmental risk assessment, Aimee's research has real world impact on the protection of human health and the environment.

Through a lonstanding collaboration with industrial partner AstraZeneca and contacts at Defra and the Environment Agency, Aimee's research on minimal selective concentrations of antibiotics is of interest to policy makers and industry at the national and international level. She has presented her research to the All Party Parliamentary Group on Antibiotics alongside University of Exeter colleagues with the aim to generate amendments to the Environment Bill. Her research was reviewed during the prioritisation process to include antibiotics and antimicrobial resistance in the EU Commission's Water Framework Directive Watch List. She has also been consulted by the United Nations Environment Programme as an expert on environmental risk assessment of antimicrobial resistance. Authored and co-authored papers have been cited by the UK Government, Environment Agency, Joint Programming Initiative on AMR, Food and Agricultural Organisation, World Health Organisation, and the United Nations Environment Programme.

Aimee is based in Cornwall at the Environment & Sustainbility Institue, Penryn and the European Centre for Environment and Human Health, Truro.

Qualifications

  • Fellowship of the Higher Education Academy 2020
  • PhD Medical Sciences, University of Exeter 2017
  • BSc Biology, 1st Class Hons, University of Bath 2013

Career

Aimee was awarded the Eliahou Dangoor Scholarship and Leonard Broadbent Prize at the University of Bath, where she graduated with 1st Class Honours in 2013.

Aimee joined the European Centre for Environment in Human Health (ECEHH) in 2013 to undertake her BBSRC/ AstraZeneca CASE funded PhD studies.

Following the award of her PhD, Aimee secured a NERC Industrial Innovation Research Fellowship to develop the first assay which can generate data on selection for antimicrobial resistance and be used for environmental risk assessment.

She will commence her proleptic lectureship at the University of Exeter summer 2021.

Research group links

Research

Research interests

  • Evolution and selection of antimicrobial resistance at low concentrations of antimicrobials
  • Environmental risk assessment of antimicrobial resistance
  • Co-selection for antimicrobial resistance by biocides, pharmaceuticals and plant protection products
  • Antimicrobial resistance and microplastics

Research projects

  • Development and validation of the first environmental risk assessment tool to protect against selection for antimicrobial resistance in situ 
  • Developing a conceptual framework to improve understanding of AMR in livestock systems: translating research into policy and practice 
  • Investigating selection for antimicrobial resistance by non-antibiotic drugs in freshwater microbial communities 
  • Investigating selection and co-selection for antimicrobial resistance by pharmaceuticals and other contaminants of concern 
  • Characterisation of novel substances in wastewater that select for antimicrobial resistance 
  • Antimicrobial Resistance (AMR) Alliance: A new approach to AMR surveillance
  • Potential co-selection for antimicrobial resistance by biocides used in shale gas extraction 
  • Exploring antibiotic use practices in livestock production through a novel, game-based approach; GAMR 
  • Understanding agricultural azole use, impacts on local water bodies and AMR: building an interdisciplinary evidence base in Devon and Bristol 
  • Hotspots for selection of and transmission of antibiotic resistance in the terrestrial environment 
  • Microplastics as vectors for pathogenic and antibiotic resistant bacteria 
  • Raising awareness and understanding of antimicrobial resistance in Key Stage 4 Cornish students

Research grants

  • 2019 NERC
    Investigating selection for antimicrobial resistance by non-antibiotic drugs in freshwater microbial communities
  • 2019 BBSRC PhD Studentship
    Investigating selection and co-selection for antimicrobial resistance by pharmaceuticals and other contaminants of concern
  • 2019 Royal Society of Biology
    Raising awareness of antimicrobial resistance and One Health in Cornish Key Stage 4 students
  • 2019 BBSRC
    BBSRC UK-Argentina Joint Call on AMR
  • 2018 QUEX Accelerator
    QUEX Antimicrobial Resistance (AMR) Alliance: A new approach to AMR surveillance
  • 2017 NERC Industrial
    Development and validation of the first environmental risk assessment tool to protect against selection for antimicrobial resistance in situ

Publications

Key publications | Publications by category | Publications by year

Key publications


Murray AK, Zhang L, Yin X, Zhang T, Buckling A, Snape J, Gaze WH (2018). Novel insights into selection for antibiotic resistance in complex microbial communities. mBio, 9(4). Abstract.  Full text.
Murray AK, Lee J, Bendall R, Zhang L, Sunde M, Slettemeås JS, Gaze W, Page AJ, Vos M (2018). Staphylococcus cornubiensis sp. nov. a member of the staphylococcus intermedius group (SIG). International Journal of Systematic and Evolutionary Microbiology, 68(11), 3404-3408. Abstract.  Full text.

Publications by category


Journal articles

Stanton IC, Murray AK, Zhang L, Snape J, Gaze WH (2020). Evolution of antibiotic resistance at low antibiotic concentrations including selection below the minimal selective concentration. Commun Biol, 3(1). Abstract.  Author URL.  Full text.
Murray AK (2020). The Novel Coronavirus COVID-19 Outbreak: Global Implications for Antimicrobial Resistance. Frontiers in Microbiology, 11 Full text.
Murray AK, Stanton IC, Wright J, Zhang L, Snape J, Gaze WH (2020). The ‘SELection end points in Communities of bacTeria’ (SELECT) Method: a Novel Experimental Assay to Facilitate Risk Assessment of Selection for Antimicrobial Resistance in the Environment. Environmental Health Perspectives, 128(10), 107007-107007. Full text.
Murray AK, Zhang L, Snape J, Gaze WH (2019). Comparing the selective and co-selective effects of different antimicrobials in bacterial communities. International Journal of Antimicrobial Agents Abstract.  Full text.
Zhang L, Calvo-Bado L, Murray AK, Amos GCA, Hawkey PM, Wellington EM, Gaze WH (2019). Novel clinically relevant antibiotic resistance genes associated with sewage sludge and industrial waste streams revealed by functional metagenomic screening. Environment International, 132 Abstract.  Full text.
Djenadi K, Zhang L, Murray AK, Gaze WH (2018). Carbapenem resistance in bacteria isolated from soil and water environments in Algeria. Journal of Global Antimicrobial Resistance, 15, 262-267. Abstract.  Full text.
Leonard AFC, Zhang L, Balfour AJ, Garside R, Hawkey PM, Murray AK, Ukoumunne OC, Gaze WH (2018). Exposure to and colonisation by antibiotic-resistant E. coli in UK coastal water users: Environmental surveillance, exposure assessment, and epidemiological study (Beach Bum Survey). Environment International, 114, 326-333. Abstract.  Full text.
Murray AK, Zhang L, Yin X, Zhang T, Buckling A, Snape J, Gaze WH (2018). Novel insights into selection for antibiotic resistance in complex microbial communities. mBio, 9(4). Abstract.  Full text.
Murray AK, Lee J, Bendall R, Zhang L, Sunde M, Slettemeås JS, Gaze W, Page AJ, Vos M (2018). Staphylococcus cornubiensis sp. nov. a member of the staphylococcus intermedius group (SIG). International Journal of Systematic and Evolutionary Microbiology, 68(11), 3404-3408. Abstract.  Full text.
Lee J, Murray A, Bendall R, Gaze W, Zhang L, Vos M (2015). Improved detection of Staphylococcus intermedius group in a routine diagnostic laboratory. Journal of Clinical Microbiology, 53(3), 961-963. Abstract.  Full text.

Publications by year


2020

Stanton IC, Murray AK, Zhang L, Snape J, Gaze WH (2020). Evolution of antibiotic resistance at low antibiotic concentrations including selection below the minimal selective concentration. Commun Biol, 3(1). Abstract.  Author URL.  Full text.
Stanton I (2020). Selection for antibiotic resistance in complex microbial communities.  Abstract.  Full text.
Murray AK (2020). The Novel Coronavirus COVID-19 Outbreak: Global Implications for Antimicrobial Resistance. Frontiers in Microbiology, 11 Full text.
Murray AK, Stanton IC, Wright J, Zhang L, Snape J, Gaze WH (2020). The ‘SELection end points in Communities of bacTeria’ (SELECT) Method: a Novel Experimental Assay to Facilitate Risk Assessment of Selection for Antimicrobial Resistance in the Environment. Environmental Health Perspectives, 128(10), 107007-107007. Full text.

2019

Murray AK, Zhang L, Snape J, Gaze WH (2019). Comparing the selective and co-selective effects of different antimicrobials in bacterial communities. International Journal of Antimicrobial Agents Abstract.  Full text.
Zhang L, Calvo-Bado L, Murray AK, Amos GCA, Hawkey PM, Wellington EM, Gaze WH (2019). Novel clinically relevant antibiotic resistance genes associated with sewage sludge and industrial waste streams revealed by functional metagenomic screening. Environment International, 132 Abstract.  Full text.

2018

Djenadi K, Zhang L, Murray AK, Gaze WH (2018). Carbapenem resistance in bacteria isolated from soil and water environments in Algeria. Journal of Global Antimicrobial Resistance, 15, 262-267. Abstract.  Full text.
Leonard AFC, Zhang L, Balfour AJ, Garside R, Hawkey PM, Murray AK, Ukoumunne OC, Gaze WH (2018). Exposure to and colonisation by antibiotic-resistant E. coli in UK coastal water users: Environmental surveillance, exposure assessment, and epidemiological study (Beach Bum Survey). Environment International, 114, 326-333. Abstract.  Full text.
Murray AK, Zhang L, Yin X, Zhang T, Buckling A, Snape J, Gaze WH (2018). Novel insights into selection for antibiotic resistance in complex microbial communities. mBio, 9(4). Abstract.  Full text.
Murray AK, Lee J, Bendall R, Zhang L, Sunde M, Slettemeås JS, Gaze W, Page AJ, Vos M (2018). Staphylococcus cornubiensis sp. nov. a member of the staphylococcus intermedius group (SIG). International Journal of Systematic and Evolutionary Microbiology, 68(11), 3404-3408. Abstract.  Full text.

2015

Lee J, Murray A, Bendall R, Gaze W, Zhang L, Vos M (2015). Improved detection of Staphylococcus intermedius group in a routine diagnostic laboratory. Journal of Clinical Microbiology, 53(3), 961-963. Abstract.  Full text.

Aimee-Murray Details from cache as at 2021-05-07 11:41:48

Refresh publications

External Engagement and Impact

Awards

  • 1st Place poster prize 2016 (British Society for Antimicrobial Chemotherapy)
  • Leonard Broadbent Prize (University of Bath)
  • Eliahou Dangoor Scholarship (University of Bath)

Invited lectures

  • AMR Industry Alliance Jan 2021.
  • All-Party Parliamentary Group on Antibiotics meeting, Nov 24th 2020. “Antibiotic residues in sewage and agricultural run-off: can we determine safe thresholds to combat deadly superbugs?”
  • EHMA conference invited panel member 2020. “Environmental Sustainability in the Health Care Sector: A shared ambition and collective efforts”.
  • WSA Alliance webinar: “AMR in water systems.” 20th November, 2020.
  • Cefas AMR Reference Centre 2019. “A novel method to determine effect concentrations of antibiotics that select for antibiotic resistance.”

Media Coverage

  • Better thresholds of antibiotics in the environment needed (Times, Times Radio, Daily Mail, MSN, 2020)
  • New pathogenic species of bacteria Staphylococcus cornubiensis (BBC Devon & Cornwall Live, Daily Mail, Cornwall Live 2018)
  • Low levels of antibiotics and selection for resistance (Centre for Infectious Disease Research and Policy, 2018)

Teaching

Undergraduate teaching

  • BMBS degree guest lecturer
  • Research and Global and Planetary Health SSU provider

Postgraduate teaching

  • MSc Contemporary Environments and Human Health guest lecturer

Modules

2020/21

Information not currently available


Supervision / Group

Postgraduate researchers

  • Leah Clarke UQ-Exeter PhD student
  • April Hayes NERC FRESH CDT PhD with AstraZeneca CASE support
  • Laura Murray BBSRC/ AstraZeneca iCASE PhD
  • Emily Stevenson MSci Supervisor

Alumni

  • Joanne Glasson MSci Supervisor
  • Isobel Stanton BBSRC PhD student co-supervisor

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