Publications
Raif Yuecel
Characterising phagocytes and measuring phagocytosis from live Galleria mellonella larvae
Jennie S Campbell 1, James C Pearce 1, Attila Bebes 2, Arnab Pradhan 3, Raif Yuecel 2, Alistair J P Brown 3, James G Wakefield 1
King J, Dambuza IM, Reid DM, Yuecel R, Brown GD, Warris A. Detailed characterisation of invasive aspergillosis in a murine model of X-linked chronic granulomatous disease shows new insights in infections caused by Aspergillus fumigatus versus Aspergillus nidulans. Front Cell Infect Microbiol. 2023 Sep 1;13:1241770
Avelar GM,, …Yuecel, R…. Brown AJP. Impact of changes at the Candida albicans cell surface upon immunogenicity and colonisation in the gastrointestinal tract. Cell Surf. 2022 Oct 17;8:100084
de Assis, LJ, …Yuecel, R…. Brown AJP. Nature of β-1,3-Glucan-Exposing Features on Candida albicans Cell Wall and Their Modulation. mBio, 2022 Oct 11;e0260522.
Stappers MHT, Nikolakopoulou C, Wiesner DL, Yuecel R, Klein BS, Willment JA, Brown GD
Characterization of antifungal C-type lectin receptor expression on murine epithelial and endothelial cells in mucosal tissues. Eur J Immunol. 2021, 51(9):2341-2344
Tone K, Stappers MHT, Hatinguais R, Dambuza IM, Salazar F, Wallace C, Yuecel R, Morvay PL, Kuwano K, Willment JA, Brown GD (2021) MelLec Exacerbates the Pathogenesis of Aspergillus fumigatus-Induced Allergic Inflammation in Mice. Front Immunol. 2021 May 28;12:675702
Schaefer K, Dambuza IM, Dall'Angelo S, Yuecel R, Jaspars M, Trembleau L, Zanda M, Brown GD, Netea MG, Gow NAR. A Weakened Immune Response to Synthetic Exo-Peptides Predicts a Potential Biosecurity Risk in the Retrieval of Exo-Microorganisms.
Microorganisms 2020, 8(7):1066
Haydn FT, Yuecel R and Gutierrez T (2020) Hydrocarbon-Degrading Bacteria Found Tightly Associated with the 50–70 μm Cell-Size Population of Eukaryotic Phytoplankton in Surface Waters of a Northeast Atlantic Region
Microorganisms 2020, 8(12): 1955
Ballard E, Yucel R, Melchers WJG, Brown AJP, Verweij PE, Warris A (2020) Antifungal Activity of Antimicrobial Peptides and Proteins against Aspergillus fumigatus. J Fungi (Basel). May 18;6(2):65
Abbas, H, Broche, LM, Ezdoglian A, Li, D, Yuecel, R, Ross, PJ, Cheyne, L, Wilson, HM, Lurie, DJ, Dawson DK (2020), Fast field-cycling magnetic resonance detection of intracellular ultra-small iron oxide particles in vitro: Proof-of-concept J Magn Reson, 313: 106722
Li, D, Roca, M, Yuecel, R and Lorenz, A (2019) Immediate visualization of recombination events and chromosome segregation defects in fission yeast meiosis Chromosoma, p1-12 https://doi.org/10.1007/s00412-019-00691-y
Damiani E, Yuecel R, Wallace HM (2019), Repurposing of idebenone as a potential anti-cancer agent. Biochem J. 25;476(2)
Scally, C., Abbas, H.,… Yuecel, R., … & Dawson, D. K. (2019) Myocardial and Systemic Inflammation in Acute Stress-Induced (takotsubo) Cardiomyopathy
Circulation, 139:1581–1592
Dambuza,I, Drake, T, Taylor-Smith, Chapuis, A, LeGrave, N, Rasmussen, T, Fisher, MC, Bicanic, T, Harrison, T, Jaspars, M, May, R, Brown, GD, Yuecel, R, MacCallum, DM, and Ballou, ER (2018), The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesis
PLoS Pathogens. 14 (5)
Stappers, MHT, Clark, AE,... Yuecel, R, ...and Brown, GD (2018), Recognition of DHN-melanin by the C-type lectin, MelLec, is required for protective immunity to Aspergillus fumigatus
Nature 555, 382–386
Pradhan A, Herrero-de-Dios C, Belmonte R, Budge S, Lopez Garcia A, Kolmogorova A, Lee KK, Martin BD, Ribeiro A, Bebes A, Yuecel R, Gow NAR, Munro CA, MacCallum DM, Quinn J and Brown AJP (2017), Elevated catalase expression in a fungal pathogen is a double-edged sword of iron.
PLoS Pathog. 22;13(5)
Collins C, Hall M, Bruno D, Sokolowska J, Duncan L, Yücel R, McCarthy U, Fordyce MJ, Pert CC, McIntosh R and MacKay Z (2017), Generation of Paramoeba perurans clonal cultures using flow cytometry and confirmation of virulence.
J Fish Dis. 40:351-365.
Mukhopadhya, I, Murray, GI, Yuecel , R, Duncan, L, Shattock, R, Kelly, C, Iannelli, F, Pozzi, G, El-Omar, EM, Hold, GL and Hijazi, K (2016), Transporters for antiretroviral drugs in colorectal CD4+ T cells and circulating α4β7 integrin CD4+ T cells: Implications for HIV microbicides.
Mol Pharm. 13:3334-40.
Sutherland AG, Cook A, Miller C, Duncan L, Yuecel R, Heys SD, Hutchison JD and Liversidge J (2015), Older Patients Are Immunocompromised by Cytokine Depletion and Loss of Innate Immune Function After HIP Fracture Surgery.
Geriatr Orthop Surg Rehabil. 6:295-302.
Liversidge, L, Yuecel , R, Forrester, M, Yeoh, J, Wallace, C, Keech, F, Reid, DM, and Basu, N (2014), Positive correlation between IL-23 and response to anti-TNF-alpha therapy in RA patients resistant to conventional therapy.
BSI Abstract, Immunology 143:150-150
Pargmann, D, Yücel, R, Kosan, C, Klein-Hitpass, L, Schimmer, S, Dittmer, D and Möröy, T (2007), Differential impact of the transcriptional repressor Gfi1 on mature CD4+ and CD8+ T lymphocyte function.
Eur J Immunol. 37:3551-63.
Geh, S. Höhr, D, Borm, P-JA, Duffin, R, Yücel, R, Armbruster, L, Raulf-Heimsoth, M, Brüning, T, Hoffmann, E, Rettenmeier, AW and Dopp, E (2006), Cellular uptake and cytotoxic potential of respirable bentonite particles with different quartz contents and chemical modifications in human lung fibroblasts.
Arch Toxicol 80:98-106.
Rathinam, C, Geffers, R, Yücel, R, Buer, J, Welte, K, Möröy, T and Klein, C (2005) , The transcriptional repressor Gfi1 controls STAT3-dependent dendritic cell development and –function.
Immunity 22:717-28.
Zeng, H, Yücel, R, Kosan, C, Klein-Hitpass, L and Möröy, T (2004), Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells.
EMBO J 23:4116-25.
Hertzano, R, Montcouquiol, M,Rashi-Elkeles, S, Elkon, R, Yücel, R, Frankel, WF, Rechavi, G, Möröy T, Friedman, TB, Kelley, MW and Avraham, KW (2004) Transcription profiling of inner ears from Pou4f3ddl/ddl identifies Gfi1 as a target of the Pou4f3 deafness gene.
Hum Mol Genet 13:2143-53.
Yücel, R, Kosan, C, Heyd, F and Möröy, T (2004) Gfi1:GFP knock-in mutant reveals differential expression and auto-regulation of the gene Growth factor independence 1 (Gfi1) during lymphocyte development.
J Biol Chem 279:40906-17.
Yücel, R, Karsunky, H, Klein-Hitpass, L and Möröy, T (2003) The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus.
J Exp Med 197:831-44.
Geisen, C, Karsunky, H, Yücel, R and Möröy, T (2003) Loss of p27(Kip1) cooperates with cyclin E in T-cell lymphomagenesis.
Oncogene 22:1724-9.
Molenaar, D, van der Rest, ME, Drysch, A and Yücel, R (2000), Functions of the membrane-associated and cytoplasmic malate dehydrogenases in the citric acid cycle of Corynebacterium glutamicum.
J Bacteriol 182:6884-91.
George Vere
Damianou, A., Liang, Z., Lassen, F., Vendrell, I., Vere, G., Hester, S., Charles, P. D., Pinto-Fernandez, A., Santos, A., Fischer, R. Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex. Life Science Alliance 7.5 (2024).
Houlder, E. L., Gago, S., Vere, G., Conn, D., Khan, S., Thomson, D., Shepherd, M., Lebedinec, R., Brown, G. D., Bromley, M. Aspergillus-mediated allergic airway inflammation is triggered by dendritic cell recognition of a defined spore morphotype, a process that can be targeted via antifungal therapeutics. bioRxiv (2024), pp. 2024–01.
Vere, G., Alam, M. R., Farrar, S., Kealy, R., Kessler, B. M., O’Brien, D. P., and Pinto-Fernandez, A. Targeting the Ubiquitylation and ISGylation Machinery for the Treatment of COVID-19. Biomolecules 12.2 (2022), p. 300.
Earle, K., Valero, C., Conn, D. P., Vere, G., Cook, P. C., Bromley, M. J., Bowyer, P., and Gago, S. Pathogenicity and virulence of Aspergillus fumigatus. Virulence 14.1 (2023), p. 2172264.
Pinto-Fernandez, A., Salio, M., Partridge, T., Chen, J., Vere, G., Greenwood, H., Olie, C. S., Damianou, A., Scott, H. C., Pegg, H. J. Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity. British Journal of Cancer 124.4 (2021), pp. 817–830.
Ruiz, E. J., Pinto-Fernandez, A., Turnbull, A. P., Lan, L., Charlton, T. M., Scott, H. C., Damianou, A., Vere, G., Riising, E. M., Da Costa, C. USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. Elife 10 (2021), e71596.
Vere, G., Kealy, R., Kessler, B. M., and Pinto-Fernandez, A. “Ubiquitomics: an overview and future”. Biomolecules 10.10 (2020), p. 1453
