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Independent Fellows

Ryan Ames

BBSRC Innovation Fellow 2018 - 2021

Research interests focus on how phenotype arises from complex systems, and generating accurate representations of cellular function using integrated interaction networks.

Area of expertise:

  • Systems biology

  • Evolutionary biology

  • Genome wide studies

  • Next generation sequence data analysis

  • Network analysis

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: r.ames@exeter.ac.uk

Phone: 01392 727473

You can also visit Ryan's personal website.

Jen Creaser

MRC Skills Development Research Fellow 2018 - 2021

Brain activity is constantly changing and transitioning between different states. Characterising these transitions can give insight into healthy brain activity, such as attention and memory, and neurological disorders, such as epilepsy and depression. My research is on transient dynamics on networks inspired by, and applied to, the brain. I use tools from data analysis, mathematics, and statistics to interrogate brain imaging data to identify the timings and order of transitions that are emergent properties of brain networks. I construct and analyse mathematical network models to characterise phenomena and understand the underlying brain mechanisms.

 

Colleen Deane

MRC Skills Development Fellow 2019 - 2022

Colleen's research interests lie in skeletal muscle health and adaptation across the life course. During her Ph.D., she investigated the age-related molecular basis of skeletal muscle regeneration and subsequently completed a post-doc investigating whether a lipid-lowering drug could improve metabolic and molecular muscle responses in older adults.

As an MRC skills development fellow, Colleen will be learning and applying computation modelling skills to human data sets in order to unravel the multi-omic basis of skeletal muscle atrophy (loss) and hypertrophy (growth), across age. 

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: c.s.deane@exeter.ac.uk

Yolanda Hill

MRC-funded UKRI Innovation Fellow 2017 - 2020

Yolanda is working with Professors Jonathan Fieldsend at the University of Exeter and John Terry at the University of Birmingham, Dr Glyn Thomas at the Bristol Heart Institute and industry partner Johnson & Johnson, on her project Cardiac Positioning System (CPS) - An automated navigation system to guide catheter ablation therapy.

Holding a Bachelor's degree in Biology with Psychology from Queen Mary University of London, Yolanda then went on to complete her PhD at King's College London in Computational Cardiac Electrophysiology, modelling reentrant electrical activation waves which cause ventricular arrhythmias. Notably, her work contributed to developing a novel strategy to guide cardiac ablation therapy to treat ventricular tachycardia arising from myocardial infarction.

Yolanda's current research builds on improving the treatment of ventricular tachycardia by refining the pace mapping technique used during ablation, to reduce the risk and increase success rates of the procedure. Her work focuses on implementing machine learning algorithms to indicate the location of infarct scar tissue and critical reentrant circuit sites from electrocardiogram data. Accurate identification of these areas of diseased tissue help to guide the delivery of successful ablation therapy to terminate ventricular tachycardia.

Address: Translational Research Exchange @ Exeter, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: y.r.hill@exeter.ac.uk

Jamie Walker

Medical Research Council Career Development Fellow 2016 - 2021

Dr Jamie Walker is a Medical Research Council Research Fellow with interests in complex dynamical processes in neuroscience and neuroendocrinology. Using a multidisciplinary approach, combining predictive mathematical modelling and analysis with experimental biology, Jamie is currently focused on understanding how the hypothalamic-pituitary-adrenal (HPA) axis regulates the pulsatile secretion of vital glucocorticoid hormones, and why the dynamics of this system changes in different physiological and pathological conditions. 

Address: Centre for Biomedical Modelling and Analysis, University of Exeter, Living Systems Institute, Exeter, EX4 4QD

Email: Jamie.Walker@exeter.ac.uk 

Phone: 01392 406816