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IBCS Seminar

Innervation of the kidney in renal injury and inflammation: A cause of deranged cardiovascular control

Dr Mohammed Abdulla Department of Physiology University College Cork Ireland

Event details

Mohammed Abdulla graduated with a 1st Class BSc (Pharmacy) degree from the College of Pharmacy, University of Baghdad, Iraq in 2001. He obtained an MSc degree in Pharmacology in 2009 and then a PhD degree in Physiology in 2012 from the University of Science Malaysia in Penang, Malaysia. In 2011, Mohammed joined Edward J. Johns’s renal Physiology lab in Cork, Ireland as a Wellcome trust post-doctoral researcher investigating the role of brain angiotensin II (type 2) receptors and nitric oxide in the baroreflex control of renal sympathetic nerve activity. In November 2014, he was recruited to University College Cork (UCC) as Lecturer in Physiology, where he leads his own independent research group focusing on innervation of the kidney in renal injury and inflammation as a cause of deranged cardiovascular control. He obtained a master’s degree in teaching and learning in higher education in UCC in February 2019.

Hypertension, heart failure and diabetes/obesity related end stage renal failure are major cardiovascular diseases with high morbidity and mortality and represent a major drain on health care resources.  Renal injury and inflammation are increasingly perceived as potential causal factors in the dysregulation of the cardiovascular system in these disease states.  However, the link between renal injury and inflammation and the dysregulation of the cardiovascular system leading to hypertensive disease is unclear but involves the renal innervation which comprises afferent (sensory) and efferent (sympathetic) nerves. Experimental studies have clearly identified inflammatory cytokines mediating injury and inflammation that appear to activate the renal afferent innervation and cause a dysregulation of the reflex control of renal sympathetic nerve activity.


Hatherly Labs B10