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The MRC CMM welcomes applications from postgraduate research (PGR) students, post-doctoral researchers, medical students and clinicians wishing to pursue research questions, gain invaluable experience in cutting edge technologies and experimental design, or to obtain focused training in specific research areas within medical mycology.
>> Read more and Complete our Expression of Interest form
We welcome enquiries from excellent researchers who wish to submit a fellowship application to an external funder (for example UKRI, Wellcome Trust, Royal Society) and be hosted by the MRC Centre of Medical Mycology. We recommend that you first contact the Centre, or an individual academic to discuss your ideas. Secondly, please complete our form at the link below and attach your supporting information. We have an internal mentoring process to ensure that the applications we support are of the highest standard.
Vacancies
Academic positions at MRC CMM
The MRC CMM seeks to appoint two new Principal Investigators and world leaders in their fields to join our exceptional team of scientists and clinicians in order to strengthen our research in the areas of:
• Antifungal Drug Resistance; This post will be aimed at recruiting an individual with an interest in understanding the underlying mechanisms of antifungal drug resistance.
• Infectious Co-morbidities; This post will be aimed at recruiting an individual whose research focuses on understand how fungal co-morbidities (especially co-infections with viruses, bacteria or helminths) influence immunity and disease pathology.
*If you are interested in these positions we recommend that you apply as soon as possible. This is a rolling-recruitment campaign and applications will be reviewed immediately upon application.
Postdoctoral Research Fellow: ADP-ribosylation signalling in the regulation of the DNA damage response (DDR) of Aspergillus fumigatus
This new full-time post is available from 1 September 2023 until 28 February 2026.
We have an exciting opportunity for a Postdoctoral Researcher to join Dr Johannes Rack’s research team, which focuses on the understanding of the role of ADP-ribosylation signalling in the regulation of the DNA damage response (DDR) of Aspergillus fumigatus. This multidisciplinary project aims to elucidate both the underlying molecular mechanisms as well as the physiological outcomes of ADP-ribosylation signalling on fungal survival, virulence, and diseases progression.
As post-holder you will be responsible for establishing new techniques to manipulate protein levels in vivo and use these tools to characterise proteins involved in the establishment and removal of the ADP-ribosylation signal as well as investigate the downstream effects of DNA damage-induced ADP-ribosylation on DNA repair pathways, fungal viability, and pathogenicity. Experience in Aspergillus cultivation and genetics as well as microscopy are essential, and mouse handling experience is highly desirable. An ability to work collaboratively across the disciplines of microbiology, biochemistry, and structural biology – in particular around DNA repair – would also be an advantage. In addition, you will provide guidance to less experienced members of the research group and assist in research communication, including manuscript writing, conference attendance, and outreach activities. Enthusiasm to creatively think “outside of the box” is much appreciated. This is an ideal post for a candidate looking for a steppingstone to independent PI positions.
Application closing date: 15/06/2023
PhD: iCASE: Looking for an Achilles Heel in the deadly fungi that cause Mucormycosis
Funded PhD Project: (UK citizens only).
Invasive infections by Mucorales fungi are life-threatening complications of severe blast trauma. Mucorales are resistant to most antifungals and cause devastating infections, yet are poorly understood. Mucorales are soil-swelling fungi and can host endosymbiotic bacteria that can influence fungal pathogenicity. We showed that removing endosymbionts can reduce fungal fitness. This project will identify compounds that target this partnership as an Achilles Heel as a strategy to mitigating fungal infections.
Closing date: Friday 16th June 2023