The Mental Health Research Group Seminar with Professor Seth Love

Reduced cerebral blood flow is a major risk factor for dementia. It causes additive brain damage and in some forms of dementia contributes to the underlying neurodegenerative disease processes. Although some of the hypoperfusion in dementia is attributable to structural changes to blood vessels (including arteriosclerotic small vessel disease and cerebral amyloid angiopathy) and to reduced metabolic demand, much results from disturbances of vascular function. In this talk I shall discuss the post-mortem measurement of myelin proteins and mediators of vascular function as a means of assessing physiological and pathological processes involved in the regulation of cerebral perfusion. I shall also present data on the diverse ways in which abnormal regulation of vascular contractility contributes to grey and white matter hypoperfusion in Alzheimer’s disease, dementia with Lewy bodies and vascular dementia.

For further information please contact Wendy Cowell: wendy.cowell@exeter.ac.uk

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