Overview:

My research is focused on understanding how microbial cells interact with their environment both as a community and as individual cells with an emphasis on AMR. Besides standard microbiology techniques and omics approaches, we develop bespoke microfluidic devices that enable us to accurately control the microenvironment surrounding the cells and perform a series of functional assays on the very same cell. This allows us to shed light on the physiology of rare subpopulations of phenotypically resistant cells that are generally hidden in ensemble measurements on clonal populations.

Key publications:

Investigating the physiology of viable but non-culturable bacteria by microfluidics and time-lapse microscopy

Fluorescent macrolide probes – synthesis and use in evaluation of bacterial resistance

Single-cell microfluidics facilitates the rapid quantification of antibiotic accumulation in Gram-negative bacteria

Key project:

Understanding antibiotic uptake and efficacy in single cells via microfluidics and omics

External engagement:

Royal Society Single-cell Ecology 2018

Full academic profile:

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